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Exploration of simultaneous dual-isotope imaging with multiphoton modular J-PET scanner

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Beyene E. Y. , Das M. , Durak-Kozica M. , Korcyl G. , Mryka W. , Niedźwiecki S. , Parzych S. , Tayefi K. , Walczak R. , Wawrowicz K. , Stępien E. , Moskal P.

Bio-Algorithms and Med-Systems

2023

tom Vol. 19, no. 1

101--108

The modular J-PET scanner, comprising 24 compact and versatile modules, each consisting of 13 plastic strips with four SiPM detectors at the ends, represents a powerful tool for clinical applications in nuclear medical imaging. This study presents preliminary results from the exploration of simultaneous dual-isotope imaging using the modular J-PET system. Our approach involved two isotopes: 68Ge, characterized by a ringlike shape, and 22Na, exhibiting a point-like shape. The imaging was based on double-coincidence and triple-coincidence events. In the double coincidence case, both isotopes contributed comparably, whereas in the triple coincidence case 22Na dominated due to the prompt gamma being emitted with 100% of positron emissions, unlike 68Ga, where the prompt gamma was emitted in only 1.3% of cases after positron emission. In this work we present direct 2γ images determined for two-signal events and images for three-signal events, with two signals from annihilation photons and one from a prompt gamma. These results showcase the preliminary findings from simultaneous dual-isotope imaging of 68Ga and 22Na isotopes using the modular J-PET scanner, which will be presented and discussed.

Development of correction techniques for the J-PET scanner

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Das M. , Bayerlein R. , Sharma S. , Parzych S. , Niedzwiecki S. , Badawi R. D. , Beyene E. Y. , Chug N. , Curceanu C. , Czerwiński E. , Eliyan K. V. , Głowa B. , Hubalewska-Dydejczyk A. , Kacprzak K. , Kaplanoglu T. , Kasperska K. , Korcyl G. , Khreptak A. , Kubat K. , Kumar D. , Lisowski E. , Lisowski F. , Mędrala-Sowa J. , Moyo S. , Mryka W. , Opalińska M. , Pandey P. , Rädler M. , Skurzok M. , Sowa-Staszczak A. , Spencer B. A. , Tanty P. , Ardebili K. T. , Venadan A. K. , Perez del Rio E. , Stępień E. Ł. , Moskal P.

Bio-Algorithms and Med-Systems

2024

tom Vol. 20, no. 1

101--110

Objective: Positron emission tomography (PET) is a widely used medical imaging technique that allows for non-invasive imaging of metabolic processes. However, traditional PET scanners rely on costly inorganic scintillators that limit their accessibility, especially in light of emerging long axial field-of-view devices. The modular J-PET scanner, an innovative alternative, uses 50-cm-long plastic scintillator strips, offering a cost-effective and modular solution. In this study we develop and assess the PET data correction techniques required for quantitative image reconstruction. Methods: We present methods for attenuation correction, random coincidence correction using the delayed time window (DTW) technique and scatter correction based on Monte Carlo simulations. Phantom studies using the NEMA IQ phantom were performed to qualitatively evaluate these corrections. Results: The results demonstrate that our implemented corrections for attenuation and random and scattered coincidences successfully improve the uniformity of tracer distribution in homogenous volumes and significantly reduce undesired activity in cold regions. Despite limitations in sensitivity and axial resolution, the applied correction techniques effectively enhance image quality, providing promising results for future applications. Conclusions: These findings highlight the potential of the modular J-PET system to offer affordable PET imaging and to pave the way for a total-body PET scanner based on plastic scintillators. Future work will focus on quantitative validation and the implementation of these corrections for human subject imaging.