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2 Acta Biochimica Polonica

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Coupling of glutathione system and synaptosmal membrane state under L-methionine treatment against oxidative stress

100%

Slyshenkov V. S. , Shevalye A. A. , Moiseenok A. G.

tom 53

nr Supplement 1

Protective role of L-methionine against free radical damage of rat brain synaptosomes

100%

Slyshenkov V. S. , Shevalye A. A. , Liopo A. V. , Wojtczak L.

Acta Biochimica Polonica

2002

tom 49

nr 4

Incubation of rat brain synaptosomal/mitochondrial fraction with ieri-butyl- hydroperoxide resulted in accumulation of the lipid peroxidation product, conjugated dienes, damage of the synaptosomal membrane as evidenced by leakage of lactate dehydrogenase, and decrease of the total content of glutathione and of the GSH/GSSG ratio. This treatment also produced a considerable decrease of the ouabain-sensitive ATPase activity and a much smaller diminution of the activities of glutathione reductase and glutathione transferase. Preincubation of the synaptosomal/mitochon- drial fraction with 0.5 or 1.0 mM L-methionine significantly protected against lipid peroxidation, membrane damage and changes in the glutathione system produced by low (1 mM) concentrations of ieri-butylhydroperoxide and completely prevented inac- tivation of ouabain-sensitive ATPase, glutathione reductase and glutathione transferase by such treatment. The importance of L-methionine in antioxidant protection is discussed.