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1

Description of two new species of Philometra Costa, 1845 (Nematoda: Philometridae) from marine fishes off Japan, with notes on Philometroides seriolae (Yamaguti, 1935)

100%

Moravec F. , Ogawa K.

Acta Parasitologica

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2019

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tom 64

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nr 4

2

Expression and localisation of ephrin-B1, EphB2, and EphB4 in the mouse testis during postnatal development

80%

Gofur M. R. , Alam J. , Ogawa K.

Reproductive Biology

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2020

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tom 20

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nr 3

3

On two species of Philometra [Nematoda, Philometridae] from the serranid fish Epinephelus septemfasciatus in Japan

70%

Moravec F. , Ogawa K. , Suzuki M. , Miyazaki K. , Donai H.

Acta Parasitologica

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2002

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tom 47

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nr 1

EN

Two nematode species of the genus Philometra Costa, 1845 (only females), P. ocularis sp. nov. and P. managatuwo Yamagutl, 1941 were recorded from the ocular cavity and the gonad, respectively, of the serranid fish (grouper) Epinephelus septemfasciatus (Thunberg) from the coast of the Tsushima Island, Nagasaki Prefecture, Japan. The new species is mainly characterized by the presence of four conspicuously large, crescent-shaped, fleshy cephalic papillae of the external circle and two small, subterminal papilla-like projections on the caudal end. Philometra cephalus is transferred to the genus Philometroides Yamaguti, 1935 as P. cephalus (Ramachandran, 1975) comb. nov. The finding of P. managatuwo represents the second record of this species and a new host record.

4

Thyroid hormones suppress epsilon-PKC signalling, down-regulate connexin-43 and increase lethal arrhythmia susceptibility in non-diabetic and diabetic rat heart

51%

Lin H. , Mitasikova M. , Dlugosova K. , Okruhlicova L. , Imanaga I. , Ogawa K. , Weismann P. , Tribulova N.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 2

EN

We examined whether thyroid hormones affect myocardial -PKC signalling, downstream target substrate, connexin-43 (Cx43) and arrhythmogenesis in non-diabetic and diabetic rats. Diabetes was induced by a single streptozotocin injection (50mg/kg, i.v.). Triiodothyronine (T3) was applied by gavage (1µg/kg of body weight for 10 days) to 4 weeks and 9 weeks diabetic and age-matched non-diabetic rats. Western blot analysis of Cx43 and -PKC, immunofluorescence of Cx43, ultrastructure of cardiomyocytes and myocardial conduction velocity were performed. Isolated perfused heart preparation was used to test ventricular fibrillation susceptibility. T3 significantly decreased -PKC expression in non-diabetic and suppressed in diabetic rat heart ventricles. Decline of -PKC signalling was associated with decrease of Cx43 phosphorylation in diabetic and to a greater extent in non-diabetic rat hearts. However, conduction velocity was significantly decreased in diabetic while enhanced due to T3 and increased in non-diabetic T3-treated rat heart ventricles compared to non-treated. T3-induced down-regulation of Cx43 was associated with increased cardiac propensity to ventricular fibrillation. Findings indicate that activation of -PKC signalling linked with phosphorylation of Cx43 is one of the mechanisms involved in the adaptation of the heart to hyperglycemia. Suppression of -PKC and Cx43 phosphorylation by T3 abolish benefit of adaptation rendering the heart prone to lethal arrhythmias.

5

Synthesis and evaluation of novel mri contrast agents of chemically modified GD-DTPA complexes with sugars

41%

Sugiyama M. , Yamashita M. , Yu G. , Fujie M. , Ogawa K. , Ozaki N. , Aoki T. , Mizuno S. , Okada S. , Tachi K. , Aoshima K. , Sankar U. R. , Kumar B. S. , Takehara Y. , Sakahara H.

Journal of Automation Mobile Robotics and Intelligent Systems

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2009

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tom Vol. 3, No. 4

191-194

EN

MRI is one of medical diagnostic imaging technologies that can draw the cross section in the body. To obtain a clearer image, Gd complexes are often used as MRI contrast agents. Gd-DTPA (Gd-Diethylenetriaminepentaacetate, Magnevist registered trademark ) is used in particular as the MRI contrast agents. We prepared and evaluated novel MRI contrast agents that were chemically modified Gd-DTPA with sugars (represented as Gd-DTPA-Sugar) via hydrolysis route for providing specificity to target organs and tissues. Gd-DTPASugar complex showed an excellent potential for the MRI contrast agent (r1=31.2 s-1mM-1). Gd-DTPA-Sugar complexes alternatively prepared by shorter synthetic route without protection/ deprotection (hydrolysis) method showed inferior results (r1=6.3 and 8.1 s-1mM-1) to the hydlized product.

6

R&D of novel medicinal materials for curing cancer: sugar modified Gd-DTPA MRI contrast agents and phospha sugar anti-cancer agents

31%

Yamashita Y. , Yamashita M. , Fujie M. , Suyama K. A. T. , Ito S. , Reddy V. K. , Yamada M. , Ogawa K. , Ozaki N. , Nakamura S. , Aoki T. , Yu G. , Aoshima K. , Kato T. , Kamikage N. , Kiyofuji K. , Takehara Y. , Sakahara H. , Takayanagi H. , Oshikawa T. , Laurent S. , Burtea C. , Van der Elst L. , Muller R. N.

Journal of Automation Mobile Robotics and Intelligent Systems

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2009

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tom Vol. 3, No. 4

80-83

EN

Novel Sugar Dendritic Gd-DTPA Complexes for MRI Contrast Agents were prepared and evaluated by in vitro and in vivo methods. The sugar dendritic MRI contrast agents have a good blood vesse pool character, and draw blood vessels and liver cancer remarkably clearer than the clinically using Gd-DTPA. Phospha sugar derivatives or phosphorus heterocyclic derivatives provided by functional groups such as epoxide, bromide, etc., were prepared and evaluated by MTT in vitro method. These phospha sugar derivatives showed excellent activities against leukemia cells as well as solid cancer cells in fashions of (i) higher activity, (ii) wider spectra, (iii) higher selectivity and specificity distingushing healthy and cancer cells, etc., compared with the molecular targeting chemotheraputic anti-cancer agent, Gleevec.