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Stem cells and their derivatives – hopes and challenges in regenerative medicine

100%

Zuba-Surma E. K.

Engineering of Biomaterials

2014

tom Vol. 17, no. 128-129

102

Major goals of contemporary regenerative medicine focus on improvement of irreversible damage of multiple organs and tissues by employing several approaches including recent achievements of cellbased therapies and tissue engineering. Several types of stem cells (SCs) such as bone marrow (BM)- derived mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs) as well as SCs with multi- and pluripotent characteristics (PSCs) have been postulated as potential source of cells for therapy. Recently, embryonic stem cells (ESCs) and so called induced pluripotent stem cells (iPS cells) representing “genetically induced” SCs with high differentiation potential, have brought great hope to the field of regenerative medicine and clinical applications. When combined with modern accomplishments of tissue engineering including biocompatible carriers and scaffolds, SCs become leading targets for cell -based regenerative applications. Although the variety of stem/ progenitor cells have been applied in experimental therapies of several organs injuries, there is still no agreement in scientific and clinical world which subpopulation/s of cells would be the most efficient in such treatment. Moreover, multiple obstacles needs to be overcome prior to optimal application of SCs in regeneration including optimization of ex vivo isolation and expansion conditions or limiting vast adverse features of some SC fractions such as teratogenic potential of ESCs and iPS cells. Recently, stem cell- derived bioactive components such as cellular microvesicles (MVs) are postulated to play important role in mediating SC activity following transplantation. MVs representing bioactive components carrying SC- derived transcripts (mRNA, miRNA), proteins, enzymes and receptors may participate in tissue regeneration via stimulation of endogenous repair mechanism by activating endogenous target cells in damaged organs. Thus, the newest trends in regenerative medicine would focus not only on combined applications of biocompatible materials with SC subpopulations, but also with their bioactive acellular components including microvesicles. Unquestionably, successful applications of stem/ progenitor cells and their derivatives in regenerative medicine would need to be safe, ethically acceptable and therapeutically efficient. Sources and application protocols for such optimal stem cell therapy are still being optimized and need scientific discussion.

Technologia ImageStream - krok dalej niz cytometria przeplywowa

51%

Zuba-Surma E. K. , Kucia M. , Ratajczak M. Z.

Postępy Biologii Komórki

2007

tom 34

nr 2

361-376

Bone-marrow-derived stem cells - our key to longevity?

51%

Ratajczak M. Z. , Zuba-Surma E. K. , Machalinski B. , Kucia M.

2007

tom 48

nr 4

307-319

Bone marrow (BM) was for many years primarily regarded as the source of hematopoietic stem cells. In this review we discuss current views of the BM stem cell compartment and present data showing that BM contains not only hematopoietic but also heterogeneous non-hematopoietic stem cells. It is likely that similar or overlapping populations of primitive non-hematopoietic stem cells in BM were detected by different investigators using different experimental strategies and hence were assigned different names (e.g., mesenchymal stem cells, multipotent adult progenitor cells, or marrow-isolated adult multilineage inducible cells). However, the search still continues for true pluripotent stem cells in adult BM, which would fulfill the required criteria (e.g. complementation of blastocyst development). Recently our group has identified in BM a population of very small embryonic-like stem cells (VSELs), which express several markers characteristic for pluripotent stem cells and are found during early embryogenesis in the epiblast of the cylinder-stage embryo.

The ImageStream system: a key step to a new era in imaging

45%

Zuba-Surma E. K. , Kucia M. , Abdel-Latif A. , Lillard J.W.,Jr , Ratajczak M. Z.

2007

tom 45

nr 4

279-290