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2 Archivum Immunologiae et Therapiae Experimentalis

2 2001

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Malformations of angiogenesis in the low differentiated human carcinomas. Immunohistochemical study

100%

Zoltowska A. , Stepinski J. , Lewko B. , Zamorska B. , Roszkiewicz A. , Serkies K. , Kruszewski W.

2001

tom 49

nr 1

59-62

Our previous observations showed that the perivascular mesenchyma of the thin-walled vessels (capillaries) in cancers may be the source of organ-specific stem cells. We suggested that the cells forming vascular channels in altered stroma participate in the tumor development. This study was designed to examine the distribution of the vessels and their appearance in the breast, lung and colon cancers. Using immunohistochemical methods, we have shown that in the low differentiated tumors both CD31 and factor VIII antigens may be expressed in capillaries chiefly on the periphery of neoplastic foci. Many of these vessels were discontinuous, with interruptions or unformed tubules. Sporadically, CD31 protein and factor VIII antigens were not expressed in capillaries inside the very low differentiated cancer cases. It is difficult to assess by immunohistochemichal means whether the vascular malformations are the primary or secondary phenomena in the malignancy and why these abnormalities were especially visible in some low differentiated cancers.

Neural cell adhesion molecule in breast, colon and lung carcinomas

84%

Zoltowska A. , Stepinski J. , Lewko B. , Serkies K. , Zamorska B. , Roszkiewicz A. , Izycka-Swieszewska E. , Kruszewski W. J.

2001

tom 49

nr 2

91-100

Neural cell adhesion molecules (NCAM) play an important role in embryogenesis and in some tumors, especially of neuroectodermal origin. In this study, eighteen cases of invasive breast carcinoma, seven cases of sigmoid colon carcinomas and seventeen cases of the non-small cell lung carcinoma were immunostained for NCAM. The NCAM expression, usually focal, was observed in some cases only. NCAM was expressed in the membranes, in a fine granular pattern. In three cases of breast cancers, also cytoplasmic localisation of NCAM was observed, which may suggest its cytoplasmic formation. Furthermore, in three cases expression of NCAM in histologically normal ductal lobular units adjacent to invasive breast cancers without presence of this antigen in cancer tissue was observed. The immunostaining was weak or absent in sigmoid colon carcinomas. In this study we confirm observation of some authors that NCAM expression occurs in some cases of non-small cell lung carcinomas.