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1 Medycyna Weterynaryjna

1 1992

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Wplyw monenzyny i tiamuliny, podanych oddzielnie lub lacznie,na ciezarne chomiki i szczury

100%

Juszkiweicz T. , Minta M. , Wlodarczyk B. , Biernacki B.

Medycyna Weterynaryjna

1992

tom 48

nr 06

252-254

The severe toxicity due to incompatibility of ionophore antibiotics with the semi-synthetic antibiotic tiamulin is still unclear. It seems to be of interest to find whether this phenomenon could effect a prenatal development of offsprings. In the present investigation monensin and tiamulin were given orally, separately or simultaneously, on gestation days 6—11 to hamsters, and on days 6—15 to rats. Hamsters were sacrificed on day 15, whereas rats on 21 day of pregnancy. All fetuses were examined for external, internal and skeletal malformations and variations. There was no evidence of teratogenic action of both used drugs in hamsters and rats. However, in hamsters tiamulin in the dose of 45 mg/kg was found to be embryotoxic (increased frequency of resorptions) and fetotoxic (lower mean fetal weight and fetal crown-rump length), but not in rats. In both species of animals, which were given monensin or monensin and tiamulin some stimulating effects on fetal growth was recorded in comparison with the control fetuses.