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Effect of crude oil and detergent on the ary Sulphatase (E.C. 3.1.6.1.) activity in Euphausia superba and E. crystallorophias

100%

Drewa G.

nr 3-4

A possible application of cathepsin B activity determination for estimating the spread of the cervix uteri carcinoma

63%

Makarewicz R. , Drewa G.

nr 3

The value of cathcpsin B activity determination for evaluation of the extent of disease was investigated in 98 patients with the cervix uteri carcinoma and 25 women with cervix uteri dysplasia. The measurements were performed before treatment. Cathepsin B activity was estimated in serum using Z-Phe-Arg-NMec, and in tumor tissue using Z-Arg-Arg-pNA • HC1 as substrates. The mean activity of the enzyme increased both in serum and tumor tissue with progression of neoplastic disease and was dependent on the clinical stage of cervical carcinoma. It should be stressed, however, that among the patients with the clinically observed early stage of the disease, higher cathepsin B activity was observed in those in whom metastases to pelvic lymph nodes were detected than in those in whom the disease was limited to cervix uteri.

Leishmaniosis visceralis przyczyną leukopenii i małopłytkowości - opis przypadku

51%

Rozwodowska M. , Drewa G. , Rozwodowska M. M. , Wozniak A.

2001

tom 47

nr 2

Analysis of microsatellite instability and loss of heterozygosity in breast cancer with the use of a well characterized multiplex system

32%

Powierska-Czarny J. , Miscicka-Sliwka D. , Czarny J. , Grzybowski T. , Wozniak M. , Drewa G. , Czechowicz W. , Sir J.

nr 4

Analysis of microsatellite instability (MI) and loss of heterozygosity (LOH) is recommended for screening patients with sporadic and hereditary malignancies. This study shows an application of a fluorescent hexaplex PCR system for microsatellite typing on A.L.F. DNA Sequencer (Pharmacia Biotech). This technique detects changes in microsatellites providing a time-efficient, reliable and accurate method for MI and LOH analyses. The Fragment Manager software was used for automated size calculation and quantitation of DNA fragments, enabling rapid and precise measurement of allelic ratios. We examined 70 breast cancer and 70 control DNA specimens, classified all the patterns of microsatellite alterations, and set up MI and LOH assessment criteria for the automated multiplex fluorescent method.