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Virtual–real fusion maintainability verification based on adaptive weighting and truncated spot method

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Ge Z. , Zhang Y. , Wang F. , Luo X. , Yang Y.

Eksploatacja i Niezawodność

2022

tom Vol. 24, no. 4

738--746

Maintainability is an important general quality characteristic of products. Insufficient maintainability will lead to long maintenance time and high maintenance cost, thus affecting the availability of products. Maintainability verification is an important means to ensure maintainability meets design requirements. However, the cost of traditional real maintainability verification method is very high, and the virtual maintenance method has insufficient verification accuracy due to the lack of large maintenance force feedback when the human body is moving. In order to reduce the evaluation error and test sample size, the paper conducts maintainability verification based on the mixed physical and virtual maintainability test scenarios. Aiming at the problem that traditional methods are difficult to deal with the real test information and synchronous virtual simulation information in the test process, this study proposes a virtual–real fusion maintainability evaluation algorithm based on adaptive weighting and truncated SPOT (Sequential Posterior Odd Test) method. It can weigh real test information and virtual human simulation information adaptively to obtain a virtual–real fusion maintainability test sample. Then, the SPOT method is used to evaluate the maintainability of small samples. The adjustment of valve clearance, replacement of air filter element and replacement of starting motor maintenance tasks of ship engine are taken as examples for demonstration. The virtual–real fusion and virtual maintainability verification methods are respectively used for verification, and compared with the physical maintenance scenario constructed by 3D printing, indicating that the accuracy of virtual–real fusion maintainability test verification is 89%, while the virtual maintainability verification is only 33%.

LC-MS/MS method assay for simultaneous determination of the pretomanid and pyrazinamide in rat plasma by LC-MS/MS: Assessment of pharmacokinetic drug-drug interaction study

100%

Huang T. , Wang L. , Wang F. , Shen X. , Wang L.

tom Vol. 36, no. 1

7--13

In the present study, an LC-MS/MS method allowing to quantify pretomanid and pyrazinamide simultaneously in rat plasma was developed. Chromatographic separation was achieved on an Agilent Eclipse plus C18 column (100 mm × 2.1 mm, 3.5 μm; Agilent, USA) and maintained at 30 °C. Multiple reaction monitoring (MRM) using positive-ion ESI mode to monitor ion transitions of m/z 360.1 → m/z 175.1 for pretomanid, m/z 124.1 → m/z 81.0 for pyrazinamide, m/z 172.1 → m/z 128.1 for metronidazole (IS). The calibration curves showed good linear relationships over the concentration range of 50–7,500 ng mL⁻¹ for pretomanid and 500–75,000 ng mL⁻¹ for pyrazinamide. The precision and accuracy were below 15% and within ±15% of the nominal concentrations, respectively. The selectivity, recovery and matrix effect of this method were all within acceptable limits of bioanalytics. The method was applied to the analysis of plasma samples from pharmacokinetic studies in rats. The results show that the main pharmacokinetic parameters of pyrazinamide, namely, T max , t1/2, and AUC(0–t), decreased in the combined group than in the alone group.