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Chłodnice wyparne wody przeznaczone do pracy w kopalniach miedzi

100%

Litwin M. , Zalewski W.

tom T. 22, z. 3D

869--874

W pracy przedstawiono model obliczeniowy i charakterystykę cieplną prototypu wypamej chłodnicy wody przeznaczonej do pracy w kopalni miedzi.

In this paper a calculation model and thermal characteristics of the evaporative water cooler prototype working in copper mine conditions has been proposed.

Badania doświadczalne gładkorurowych oziębiaczy powietrza

100%

Litwin M. , Gologorski J.

nr 11

Powietrzne chłodnice cieczy -- alternatywa dla chłodnic wyparnych ?

80%

Litwin M. , Zalewski W. , Pacześna J.

Technika Chłodnicza i Klimatyzacyjna

2000

tom nr 4

152-156

MRI-monitored cord blood-derived cell transplantation to the ventricular system of child with global cerebral ischemia-a case report

41%

Janowski M. , Kmiec T. , Jurkiewicz E. , Kropiwnicki T. , Habich A. , Kotulska K. , Jelonek E. , Sarnowska A. , Litwin M. , Boruczkowski D. , Lukomska B. , Walecki J. , Roszkowski M. , Jozwiak S. , Domanska-Janik K.

nr 1

Introduction: Neurological disorders are the most common cause of serious disability and have a major impact on financial healthrelated burden to society. Most of them are definitely associated with cell death: sudden or chronic. Conventional treatment methods yield disappointing results. Thus the discoveries in stem cell biology have fueled the interest in cell-based therapeutical approach. Based on experimental data cord blood has been proposed as a novel, autologous cell source for pediatric population. Non-invasive monitoring of cell fate following transplantation has been recently recommended as a basis for rational stem cell therapy. Subject: One year old child experienced devastating, cardiac arrest-induced cerebral ischemia. Despite a broad rehabilitation program diagnose of vegetative state has been established three months later. After next three months of continued rehabilitation no noticeable improvement has also been found and the child has been included into study. The protocol has been approved by the ethical commission of The Children’s Memorial Health Institute in Warsaw, Poland. Then the child’s own cord blood cells have been neurally-converted over 10 days in culture within GMP facility. Prior to transplantation cells were labeled with iron oxide (SPIO) for MR imaging. For scaling sensitivity of MR signal different concentrations of SPIO-labeled cells were scanned in the phantom. Then patient received monthly 3 subsequent cell infusions (1.2 x 107 cells each) to lateral ventricles. The follow up continued up to 6 months and included both clinical assessment and MR examinations. Results: High efficiency of neural cell conversion and SPIO labeling as well as no cytotoxicity were observed. The employed method of cell transplantation was found to be efficient to deliver cells to CNS as confirmed by MR imaging. Gradual decrease of SPIO signal intensity was observed over the period of follow up. No adverse events or abnormal reaction to cell implantation was detected. The follow up revealed mild functional improvement - decreased nystagmus, spasticity and the number of epileptic seizures. Moreover, the features of the child contact with parents has appeared, thus vegetative state can not be diagnosed any more. Conclusions: This report indicates that transplantation of autologous, neurally-committed cord blood-derived cells to the ventricular system of child is safe, feasible and able to result with mild functional improvement. Additionally cell-related MRI signal can be monitored for more than 4 months in transplanted brain hemisphere. Supported by MSHE grants no 0141/B/P01/2008/35 and 0142/B/ P01/2008/35.