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The protective role of flavonoids against toxic factors on phospholipid membranes

100%

Gabrielska J. , Soczynska-Kordala M.

nr Suppl.

Time-dependent modification of model membrane properties by benzylammonium chlorides

80%

Gabrielska J. , Sarapuk J. , Kleszczynska H. , Przestalski S.

nr 3

The nature of the interaction between some strong antifungal compounds and model membranes was studied. It was found that these compounds (N-dodecyl-N,N-dimethyl-N-/3- (β-methyl-β-nitrovinyl 1-6-methoxybenzyl/ammonium chloride and its derivatives) significantly change the properties of liposomes, planar lipid bilayers (BLM) and erythrocytes. The changes observed (i.e., release of praseodymium ions from liposomes and gradually diminished stability of BLM) in the presence of the compounds studied, as well as hemolysis of red blood cells, were time-dependent. It was also found that they depended on the polar head structure of the compounds.

Quercetin reduces prooxidant action of organometallic compounds on lipsome membranes irradiated with UV

80%

Gabrielska J. , Soczynska-Kordala M. , Przestalski S.

nr 5

We studied the effects of UV radiation on the degree of phosphatidylcholine (PC) liposome membrane oxidation in the presence of such toxic organometallic compounds (TOC) as diphenyltin dichloride (DPhT), triphenyltin chloride (TPhT), dibutyltin dichloride (DBT), tributyltin chloride (TBT), triphenyllead chloride (TPhL) and tributyllead chloride (TBL). PC liposome oxidation was also investigated in the presence of quercetin (Que) and equimolar mixtures of Que and TOC in order to determine the protective properties of this natural antioxidant with respect to liposome membrane oxidation induced by UV light. Concentration of the compounds studied was 10 µM. The degree of liposome oxidation was measured using the TBARS (Thiobarbitutric Reactive Substances) test. The sequence thus obtained of relative induction of PC oxidation due to TOC was as follows: TBT > TPhT = DBT > DPhT = TPhL > TBL. The results of studies with Que indicate its high efficacy in the antioxidative action of equimolar mixtures of Que and TOC. From our study it follows that quercetin forms complexes both with phenyl- and butyl- tin and lead compounds. A high antiradical (towards DPPH radical) activity of the associates with respect to the activity of quercetin alone was also found. This result can partly explain the antioxidative properties of Que in the studied solution, connected with their antiradical action and chelating posibility towards the organometallic compounds studied. A factor that differentiates the antioxidant activity of the complexes Que-TOC is probably their differentiated location in the liposome membrane bilayer. A factor that differentiates the antioxidant activity of the complexes Que-TOC is probably their differentiated location in the liposome membrane bilayer.