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Wpływ technologii ICT na rolę konsumenta w komunikacji marketingowej

100%

Wójcik J.

Studia Ekonomiczne

2013

tom 140

112-121

Thanks to development of ICT consumers have been given new tools, which make searching for information and sharing opinions easier. New communication tools have become subject of many publications. Having read them we may come to a conclusion that consumers' role in marketing communication has increased significantly and that consumers are the dominant subject of communication process. The author of this article proves that the above conclusion is false. In fact, the author puts the opposite thesis, which says that advertisers have huge advantage observed in opportunities of common advertisements' individualization, which is done to consumers' unawareness. It doesn't matter if it is a consumer who initiates exchange of information as his/her behaviour was previously carefully monitored and controlled consequently.

NMR measurements of proton exchange between solvent and peptides and proteins

45%

Wójcik J. , Ruszczyńska K. , Zhukov I. , Ejchart A.

Acta Biochimica Polonica

1999

tom 46

nr 3

651-663

Conformational analysis of a novel cyclic enkephalinanalogue using NMR and EDMC calculations

45%

Sidor M. , Wójcik J. , Pawlak D. , Izdebski J.

Acta Biochimica Polonica

1999

tom 46

nr 3

641-650

Light conditions alter accumulation of long chain polyprenols in leaves of trees and shrubs throughout the vegetation season.

32%

Bajda A. , Chojnacki T. , Hertel J. , Swiezewska E. , Wójcik J. , Kaczkowska A. , Marczewski A. , Bojarczuk T. , Karolewski P. , Oleksyn J.

Acta Biochimica Polonica

2005

tom 52

nr 1

233-241

In many plants belonging to angiosperms and gymnosperms the accumulation in leaves of long chain polyprenols and polyprenyl esters during growth in natural habitats depends on the light intensity. The amount of polyprenols in leaves is also positively correlated with the thickness of the leaf blade (SLA, specific leaf area). The polyprenol content of leaves shows seasonal changes with a maximum in autumn and a minimum in early summer with the difference between poorly and well illuminated plants persisting throughout the vegetation season.

Cyclic enkephalin-deltorphin hybrids containing a carbonyl bridge: structure and opioid activity

32%

Ciszewska M. , Ruszczyńska K. , Oleszczuk M. , Chung N. , Witkowska E. , Schiller P. , Wójcik J. , Izdebski J.

Acta Biochimica Polonica

2011

tom 58

nr 2

225-230

Six hybrid N-ureidoethylamides of octapeptides in which an N-terminal cyclic structure related to enkephalin was elongated by a C-terminal fragment of deltorphin were synthesized on MBHA resin. The synthetic procedure involved deprotection of Boc groups with HCl/dioxane and cleavage of the peptide resin with 45 % TFA in DCM. d-Lys and d-Orn were incorporated in position 2, and Lys, Orn, Dab, or Dap in position 5. The side chains of the dibasic amino function were protected with the Fmoc group. This protection was removed by treatment with 55 % piperidine in DMF, and cyclization was achieved by treatment with bis-(4-nitrophenyl)carbonate. Using various combinations of dibasic amino acids, peptides containing a 17-, 18-, 19- or 20-membered ring structure were obtained. The peptides were tested in the guinea-pig ileum (GPI) and mouse vas deferens (MVD) assays. Diverse opioid activities were observed, depending on the size of the ring. Extension of the enkephalin sequence at the C-terminus by a deltorphin fragment resulted in a change of receptor selectivity in favor of the δ receptor. The conformational propensities of selected peptides were determined using the EDMC method in conjunction with data derived from NMR experiments carried out in water. This approach allowed proper examination of the dynamical behavior of these small peptides. The results were compared with those obtained earlier with corresponding N-(ureidoethyl)pentapeptide amides.