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D-carvone, a monoterpene reverses alterations in heart rate, nitric oxide, aortic lipids and enzymatic antioxidant status in nitric oxide deficient hypertensive rats

100%

Rajeshwari T. , Raja B.

International Letters of Natural Sciences

2015

tom 05

The present study was aimed to assess the antihyperlipidemic, antihypertensive and antioxidant effect of D-carvone, a monoterpene against Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension. Hypertension was prompted in adult male albino rats of the Wistar strain by oral administration of the L-NAME (40 mg/kg body weight) in drinking water for 4 weeks. Rats were treated with D-carvone (5, 10 and 20 mg/kg body weight) for four weeks. L-NAME treated rats exhibited significant increase in water intake, heart rate, aortic lipids level such as triglycerides (TG), total cholesterol (TC), free fatty acids (FFA) and significant decrease in the level of phospholipids (PL), plasma nitric oxide (NO). The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were decreased in erythrocytes of L-NAME induced hypertensive rats. Treatment with D-carvone restored all the above parameters to near normal level. These results suggest that D-carvone acts as an antihyperlipidemic, antihypertensive and antioxidant agent against L-NAME induced hypertensive rats.

Antioxidant and free radical scavenging effect of D-carvone in hypertensive rats. In vivo and in vitro study

100%

Rajeshwari T. , Raja B.

International Letters of Natural Sciences

2015

tom 08

This study was planned to assess the antioxidant and free radical scavenging effect of D-carvone against L-NAME (Nω-nitro-L-arginine methyl ester hydrochloride) induced hypertension. Hypertension was encouraged in adult male albino rats of the Wistar strain, considering 180–230 g, by oral administration of the L-NAME (40 mg/kg/ body weight/day) in drinking water for 4 weeks. Rats were cured with D-carvone (5, 10 and 20 mg/kg body weight) for four weeks. A significant reduction in the levels of non-enzymatic antioxidants such as vitamin C, vitamin E and reduced glutathione (GSH), in plasma were perceived in L- NAME induced hypertensive rats. Moreover, in vitro free radical scavenging activity of ABTS+ and DPPH• radical scavenging possible of D-carvone was also quantified. Treatment with D-carvone (5, 10 and 20 mg/kg bw) carries back all the above parameters to near usual level, in which 20 mg/kg displayed the highest effect than that of other two doses. Further, D-carvone displays concentration dependent antioxidant potential. These results suggest that D-carvone acts as an antioxidant and free radical scavenging agent against L-NAME induced hypertension.

Implication and hazard of radiation level in the building materials

80%

Kekur B. , Rajeshwari T. , Siddanna R. , Kumar A.

Acta Geophysica

2013

tom Vol. 61, no. 4

1046--1056

The natural radioactivity due to radium, thorium, and potassium in building material samples contribute to the radiation dose received by human beings significantly. It is essential to evaluate the activity levels of these nuclides for the assessment of natural radiation dose. Activity concentrations of the gamma emitting primordial radionuclides 232Th, 226Ra, and 40K were measured using high resolution gamma spectrometry technique with high purity germanium (HPGe) detector in building materials: sand, brick, granite, cement and rock, collected from various areas of Gulbarga and Koppal districts. The standard ASTM procedure was followed for the sample preparation. The distribution of radionuclides and variation in activity concentration depend upon the rock formation and the geological properties of the region. The activity of the three radionuclides, 232Th, 226Ra, and 40K, were found to be in the range of 3.1-227.1, 1.6-111, and 23.2-1505 Bq/kg, respectively. The dose related radiological parameters were also calculated for all the samples and the observations show that the activity concentrations of the radionuclides are well within the UNSCEAR limits.