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1 Polish Journal of Microbiology

1 2016

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IgG avidity: an important serologic marker for the diagnosis of tick-borne encephalitis virus infection

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Vilibic-Cavlek T. , Barbic L. , Stevanovic V. , Petrovic G. , Mlinaric-Galinovic G.

Polish Journal of Microbiology

2016

tom 65

nr 1

A total of 52 serum samples from patients with symptoms suggestive of tick-borne encephalitis virus (TBEV) infection and positive IgM and/or IgG antibodies were tested for IgG avidity. Acute/recent TBEV infection was confirmed by low/borderline avidity index (AI) in 94.8% IgM positive/IgG positive samples, while in 5.2% high AI was found indicating persisting IgM antibodies. Majority of IgM negative/IgG positive samples (78.6%) showed high AI consistent with past TBEV infection. However, in 21.3% patients without measurable IgM antibodies current/recent infection was confirmed by AI. IgG avidity represents an additional serologic marker that improves diagnosis of TBEV, especially in cases of atypical antibody response.