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Glial-restricted precursors as potential candidates for ALS cell-replacement therapy

100%

Kruminis-Kaszkiel E. , Wojtkiewicz J. , Maksymowicz W.

Acta Neurobiologiae Experimentalis

2014

tom 74

nr 3

Amyotrophic lateral sclerosis is a multifactorial progressive neurodegenerative disorder leading to severe disability and death within 3-5 years after diagnosis. The main mechanisms underlying the disease progression are poorly known but according to the current knowledge, neuroinflammation is a key player in motor neurons damage. Astrocytes constitute an important cell population involved in neuroinflammatory reaction. Many studies confirmed their striking connection with motor neuron pathology and therefore they might be a target for the treatment of ALS. Cell-based therapy appears to be a promising strategy. Since direct replacement or restoring of motor neurons using various stem cells is challenging, enrichment of healthy donor-derived astrocytes appears to be a more realistic and beneficial approach. The effects of astrocytes have been examined using transplantation of glial-restricted precursors (GRPs) that represent one of the earliest precursors within the oligodendrocyte and astrocytic cell lineage. In this review, we focused on evidence-based data on astrocyte replacement transplantation therapy using GRPs in animal models of motor neuron diseases. The efficacy of GRPs engrafting is very encouraging. Furthermore, the lesson learned from application of lineage-restricted precursors in spinal cord injury (SCI) indicates that differentiation of GRPs into astrocytes before transplantation might be more advantageous in the context of axon regeneration. To sum up, the studies of glial-restricted precursors have made a step forward to ALS research and might bring breakthroughs to the field of ALS therapy in the future.

Contribution of the central mechanism and pulmonary stretch receptor reflex in respiratory sinus arrhythmia in men

88%

Tafil M. , Lipski J. , Kubin L. , Fedorko L. , Maksymowicz W.

Acta Physiologica Polonica

1979

tom 30

nr 1

Influence of kefamine on the contractile activity and reactivity of the isolated rat myometrium

88%

Talalaj M. , Lipski J. , Kubin L. , Fedorko L. , Maksymowicz W.

Acta Physiologica Polonica

1979

tom 30

nr 1

The feasibility of the CD271+ and CD271– mesenchymal stromal cell enrichment toward nucleus pulposus-like cells

75%

Jezierska-Wozniak K. , Barczewska M. , Habich A. , Wojtacha P. , Badowska W. , Maksymowicz W. , Wojtkiewicz J.

Folia Histochemica et Cytobiologica

2017

tom 55

nr 3