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3 Postępy Higieny i Medycyny Doświadczalnej

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Strategies for prevention of Gram-negative sepsis and septic shock

100%

Lukasiewicz J. , Lugowski C.

Postępy Higieny i Medycyny Doświadczalnej

2003

tom 57

nr 3

251-262

Septic shock is the most severe manifestation of infection and appears to be increasingly common, especially in the intensive care units. Lipopolisaccharides (LPS, endotoxin) are known to be responsible for the initiation of sepsis and septic shock, therefore they can be targets for new preventive and therapeutic strategies. This review focuses on endotoxin-based molecular strategies for the prevention and treatment of Gram-negative sepsis and septic shock.

Biological activities of lipopolysaccharide

100%

Lukasiewicz J. , Lugowski C.

Postępy Higieny i Medycyny Doświadczalnej

2003

tom 57

nr 1

33-53

Lipopolysaccharides (LPS, endotoxin) are known to be responsible for the initiation of endotoxic shock, therefore they can be targets for new preventive and therapeutic strategies. This review describes the biological and physicochemical properties of endotoxin ? major component of the outer membrane of Gram-negative bacteria. The paper focuses on response of the host to endotoxin, recent knowledge about the target cells and receptors for LPS, mechanisms of innate immune response and cell signal transduction due to the LPS recognition. It also summaries results of studies on LPS structure influence on its biological activity.

Bacterial endotoxins - methods of structural analysis

80%

Niedziela T. , Jachymek W. , Lugowski C.

Postępy Higieny i Medycyny Doświadczalnej

1996

tom 50

nr 5

419-429

The modern structural methods used in the determination of lipopolysaccharides chemical structures were described. The combination of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MALDI-TOF, FAB and EI) applied to structural analysis of lipopolysaccharides, with a few chosen examples of characteristic original spectra were presented.