Introduction: Retained subretinal perfluoro-n-octane droplets occur in nearly 1% of the procedures. When subretinal cystoid cavities are registered, differential diagnosis including this condition is needed. Clinical case: A 77-year-old male presented three small bubbles of perfluoro-n-octane under the papillomacular bundle after vitrectomy due to a retina redetachment, evidenced by multimodal image. Conclusions: Multimodal image can help to diagnose this condition. There are several signs that can support this diagnosis. If visual acuity is threatened, removing the bubbles is mandatory, accepting risks.
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