Wyniki wyszukiwania - Biblioteka Nauki

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

Znaleziono wyników: 3

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Spinal effects of the calmodulin inhibitor calmidazolium on dorsal horn neurons in the rat

100%

Menendez L. , Baamonde A. , Hidalgo A.

Acta Neurobiologiae Experimentalis

1999

tom 59

nr 1

31-35

Drugs able to inhibit calmodulin activation can prevent some consequences of the rise in intracellular calcium. It has recently been shown that intrathecal injection of calmodulin inhibitors induce analgesia in rats. We study here the effect induced by the calmodulin inhibitor, calmidazolium, on the activity of dorsal horn neurons driven by noxious and non-noxious stimuli. Extracellular recordings of convergent (n = 12), low-threshold mechanoreceptive (n = 5) and proprioceptive (n = 5) units were made in the presence of calmidazolium. Calmidazolium (600 mg) reduced the noxious (50oC) heat-evoked responses obtained in convergent neurons. On the contrary, the non-noxious tactile responses obtained in low-threshold mechanoreceptive neurons as well as the joint movement-evoked responses obtained in proprioceptive units remained unmodified. We conclude that calmidazolium can block nociceptive processing in the spinal cord and that this fact can help to explain the analgesic effects that intrathecal W-7 and calmidazolium induce in behavioral tests.

Effects of DAGO on the rodent hippocampal evoked potentials using different perfusion solutions

88%

San_ M. S. , Menendez L. , Gutierrez M. , Hidalgo A. , Baamonde A.

Acta Neurobiologiae Experimentalis

2000

tom 60

nr 2

187-193

Opioid receptor agonists exert excitatory effects in the hippocampus by inhibiting GABA release. We report that the mu-opioid agonist, DAGO, increases the amplitude of the population spikes (PS) measured in the stratum pyramidale of the CA1 cell layer in mouse and rat hippocampal slices perfused with an artificial cerebrospinal fluid (ACSF), but not when perfused in Krebs solution. The GABA A agonist, 3-APS, induces inhibitory responses when perfused in either ACSF or Krebs. Also, the field excitatory postsynaptic potentials (EPSP) measured on stratum radiatum do not differ when the slice is perfused with either ACSF or Krebs. The increase in the amplitude of the PS induced by DAGO is not obtained when perfused in a modified ACSF whose concentration of MgSO4 was lowered to its concentration in the Krebs solution (from 2.4 mM to 1.2 mM). Thus, changes in the concentration of MgSO4 seem to be responsible for the different responses induced by DAGO.

Template Assisted Deposition of Ferromagnetic Nanostructures: from Antidot Thin Films to Multisegmented Nanowires

63%

Prida V. M. , Salaheldeen M. , Pfitzer G. , Hidalgo A. , Vega V. , González S. , Teixeira J. , Fernández A. , Hernando B.

Acta Physica Polonica A

2017

tom 131

nr 4

822-827

The growth of nanostructured materials by means of different deposition methods employing nanoporous anodic aluminum oxide membranes as patterned templates has been widely used during last years due to the outstanding features displayed by these nanoporous templates. Here we report on the synthesis, morphology and magnetic properties exhibited by novel magnetic 1D and 2D nanostructured materials having nanowire or antidot thin films geometry, respectively, together to that of geometrically diameter modulated ferromagnetic nanowires. Their magnetic properties will be analyzed and discussed based on the different anisotropic behavior derived from their morphological and microstructural features.