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Piasecki E.

Postępy Higieny i Medycyny Doświadczalnej

1993

tom 47

nr 2

85-99

are proteinaceous infection particles. They are probably devoid of nucleic acid. (PrP) is encoded by the normal cellular gene. of prion protein has different conformation than the normal PrP protein. The exact nature of the posttranslational modification of prion protein is unknown. This modification may be caused by infection with prions infectious disease or occures spontaneously sporadic disease. Some mutations in PrP gene results in the production of pathological protein familial disease.

Seleno-organic compounds induce interferon and tumor necrosis factor in human but not in rat or mouse lymphoid

51%

Inglot A. D. , Piasecki E. , Zaczynska E. , Zielinska-Janczylik J.

Archivum Immunologiae et Therapiae Experimentalis

1992

tom 40

nr 2

169-173

The seleno-organic compounds are highly active in several anti-inflammatory assays performed in mice and rats. However, they differ from the classical non-steroidal anti-inflammatory drugs including indomethacin despite the fact that both types of drugs are inhibitors of prostaglandins and leukotrienes. Furthermore, ebselen and analogs are potent anti-oxudants in many animal cell cultures. The toxicity of the drugs is low because selenium in their structure is not bioavailable. We have discovered that the seleno-organic compounds induce interferon gamma tumor necrosis factor alpha and other cytokines in human peripheral blood leukocytes (PBL). Furthermore, the action of the drugs and PHA or Con A was synergistic. However, ebselen and analogs were found to be inactive as the cytokine inducers in cultured rat or mouse lymphoid cells. In cotrast to their effects in human PBL, the drugs even inhibited the production of IFN-gamma after stimulation with PHA or Con A. The inhibition was dose dependent. We suggest that the induction of IFN by ebselen and analogs is species specific and it may depend on interaction of the drugs with a specific receptor and/or signal-transducing system present in human but not in some animal cells.