Wyniki wyszukiwania - Biblioteka Nauki

1

Globalizacja - czy możliwe jest powtórzenie specjalizacji biologicznej w życiu społecznym?

100%

Kotwica J.

Humanistyka i Przyrodoznawstwo

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2007

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nr 13

2

Globalizacja - czy możliwe jest powtórzenie specjalizacji biologicznej w życiu społecznym?

100%

Kotwica J.

Humanistyka i Przyrodoznawstwo. Uniwersytet Warmińsko-Mazurski w Olsztynie

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2007

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tom 13

3

Instytut Rozrodu Zwierzat i Badan Zywnosci Polskiej Akademii Nauk - w dziesieciolecie powstania

100%

Kotwica J.

Medycyna Weterynaryjna

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1998

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tom 54

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nr 12

847-851

4

Role of the noradrenergic system in the secretory function of the corpus luteum

100%

Kotwica J.

Journal of Physiology and Pharmacology. Supplement

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1992

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tom 43

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nr 1

5

Involvement of arachidonic acid and its products in the mechanism of progesterone influence on its own production in vitro in bovine corpus luteum

100%

Kotwica J.

Bulletin of the Veterinary Institute in Puławy

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2004

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tom 48

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nr 3

6

Leptyna w procesach metabolizmu i rozrodu

63%

Bogacki M. , Kotwica J.

Medycyna Weterynaryjna

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2002

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tom 58

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nr 09

7

Wplyw stymulacji beta-adrenergicznej na funkcje ukladu rodnego krowy podczas cyklu rujowego i ciazy

63%

Kotwica J. , Miszkiel G.

Medycyna Weterynaryjna

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1998

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tom 54

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nr 08

523-529

8

Wplyw adrenergicznego unerwienia jajnika na jego funkcje sekrecyjna

63%

Jaroszewski J. , Kotwica J.

Medycyna Weterynaryjna

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1992

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tom 48

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nr 03

134-138

EN

Mammalian ovaries are chiefly innervated by the fibers of the adrenergic system although a cholinergic one also plays a certain role. In spite of lack any direct contact between adrenergic fibers, luteal cells and cells of the granulosa layer has been ascertained, denervation of the ovary results in malfunction of its secretory function. Noradrenaline affects the growth of ovarian vessicles as well as hastens the ovulation process. Moreover, catecholamines both in vitro and in vivo conditions stimulate the production of steroid hormones and oxytocin in ovary cells. This effect is caused by the direct action of catecholamines on membrane beta-adrenergic receptors in luteal cells as well as cells of the granular layer and theca externa. However, an indirect effect of catecholamines on ovarian hormone secretion through regulation of ovarian blood flow cannot be excluded. The amount of blood flowing through the corpus luteum is highest at the peak of its development and is dependent on the pressure in vessels carring blood to the ovary as apposed to the ovary stroma in which blood is under local autoregulation.

9

Influence of polychlorinated biphenyls on the secretion of oxytocin from bovine luteal cells and from granulosa cells obtained from the follicles of different size

63%

Mlynarczuk J. , Kotwica J.

Polish Journal of Veterinary Sciences

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2005

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tom 08

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nr 4

10

Struktura oscylatora biologicznego owadów

63%

Bebas P. , Kotwica J.

Prace i Materiały Zootechniczne

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2008

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tom 66

11

Effect of polychlorinated biphenyls (PCBs) on basal and OT-stimulated calcium concentrations in myometrial cells in cows

63%

Wrobel M. , Kotwica J.

Reproductive Biology

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2005

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tom 05

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nr 3

12

Mechanizm wplywu katecholamin na funkcje wydzielnicza komorek jajnikowych

63%

Pesta M. , Kotwica J.

Medycyna Weterynaryjna

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1992

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tom 48

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nr 04

168-171

EN

Noradrenaline released from ovarian neural terminals and also that attaining the ovary together with blood stimulates steroidogenic process in ovarian cells, as well as, secretion of ovarian oxitocin acting by means of beta-adrenergic membrane receptors. These receptors depending upon the concentration and time of catecholamine action undergo the so-called process of down-regulation and also desensitization of the cell membrane. From this perspective the noradrenergic system (independently from other regulatory factors) is an important element strenghtening ovarian secretory function both during the oestrus cycle and gestation. The in vitro studies point to a direct catecholamines action on ovarian secretory cells. However, the effect of variations in blood flow through the ovary under catecholamines influence on the secretory function of ovarian cells requires further studies.

13

Role of mesovarium and mesosalpinx in counter current exchange of hormones

63%

Kotwica J. , Krzymowski T.

Acta Physiologica Polonica

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1989

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tom 40

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nr 1

EN

Kotwica, J. and Krzymowski, T.: Role of mesovarium and mesosalpinx in counter current exchange of hormones. Acta physiol, ipol., 1989, 40 ( l ): 12-22. On the base of own studies with counter current transfer of steroid hormones and PGF,a and the data taken from the literature it is suggested that two iparts of broad ligament of the uterus i.e. mesovarium and mesosalpinx are not only morphological structures keeping the ovary, oviduct and ovarian vasculature, ibut that they may take ipart in hormonal regulation of the ovarian function.

14

Involvement of progesterone, oxytocin, and noradrenaline in the molecular regulation of steroidogenesis in the corpus luteum of the cow

63%

Rekawiecki R. , Kotwica J.

Bulletin of the Veterinary Institute in Puławy

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2008

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tom 52

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nr 4

EN

The aim of this study was to determine: (a) whether progesterone affects the expression of the gene for its own receptor, thereby affecting its own synthesis; (b) whether oxytocin (OT) and noradrenaline (NA) influence the expression of gene for receptor (R) of OT (OT-R), progesterone (PR-R), and β2-R, determined by means of real-time PCR; (c) whether OT, progesterone, and NA affects the protein level for receptors of OT and β2, determined by means of the Western blot. Luteal cells isolated from the corpus luteum (CL) on days 6-10 and 11-16 of the oestrous cycle were used in the study. The luteal cells were treated with luteinising hormone (LH; 100 ng/mL), progesterone (10⁻⁵ M), OT (10⁻⁷ M), NA (10⁻⁵ M), and prostaglandin (PG) E₂ (10⁻⁶ M) for 6 h for the gene expression and for 24 h for the measurement of receptor protein. Thereafter, medium was collected for the determination of progesterone concentration. LH and PGE₂ increased luteal secretion of P4 on days 6-10 and 11-16 after 6 h and 24 h stimulation. LH increased expression of the gene for PR-R on days 6-10 and 11-16 but PGE₂ only on days 6-10 of the oestrous cycle. OT stimulated gene expression for its own receptor on days 11-16, while progesterone only increased OT-R protein on days 6-10 of the cycle. The obtained data suggest a positive intra-ovarian feedback mechanism between progesterone and OT that enhances the function of CL in the cow.

15

Non-genomic effect of ovarian steroids on oxytocin-stimulated prostaglandin [PG] F2alpha and E2 secretion from bovine endometrial cells

63%

Kowalik M. , Kotwica J.

Bulletin of the Veterinary Institute in Puławy

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2007

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tom 51

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nr 1

EN

The aim of the study was to establish the effect of the ovarian steroids: 17β-oestradiol (E2) and testosterone (T4) on OT-stimulated PGF2α and PGE2 secretion by bovine endometrial cells. The epithelial endometrial cells from days 14-18 of the oestrous cycle (10⁵/ml) were incubated in DMEM/Ham's F12 with 10% FCS (38°C, atmosphere of air and 5% CO₂) for 72-96 h and the last 24 h in DMEM/Ham's F12 with 0.1% BSA. In Exp.l, the doses of steroids used to study their effect on the secretion of PGF2α and PGE2 from endometrial cells stimulated by OT were determined. In Exp.2, the cells were pre-incubated for 30 min with selected doses of steroids: P4 (10⁻⁵ M), T4 (10⁻⁵ M), and E2 (10⁻⁸ M) and next for 4 d with: arachidonic acid (AA; 10⁻⁵ M), OT (10⁻⁷ M) and OT with each of these steroids. The concentration of PGE2 and PGFM -metabolite of PGF2α was determined by EIA. P4, T4, and E2 did not affect (P>0.05) the basal secretion of PGF2α and PGE2, but all the steroids inhibited (P<0.01) OT- stimulated PGF2α secretion. The stimulating effect of OT on PGE2 secretion was not affected by P4 and T4 (P>0.05). This data suggests that different cellular mechanisms exist for steroids affecting the secretion of both prostaglandins from endometrial cells. Moreover, we suggest that non-genomic effect of P4 on bovine endometrial cells is non-specific since the other steroids can impair the effect of OT on these cells. This effect of the steroids can directly modulate function of endometrial cells.

16

Influence of polychlorinated biphenyls on LH-stimulated secretion of progesterone and oxytocin from bovine luteal cells

63%

Mlynarczuk J. , Kotwica J.

Polish Journal of Veterinary Sciences

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2006

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tom 09

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nr 2

EN

Polychlorinated biphenyls (PCBs) due to their lipophilic properties can be easily accumulated in animal and human body and elicit diverse effects causing impairment of reproductive processes. Since these compounds were not be able to affect directly the luteal steroidogenesis, the aim of the present study was to verify hypothesis that PCBs can impair the effect of LH on the secretory function of luteal cells. Bovine luteal cells from different stages of the oestrous cycle (days 1-5, 6-10, 11-15 and 16-18) were exposed for 72h to various congeners of PCBs (PCB 126, PCB 77 and PCB 153) at the doses of 1, 10 or 100 ng/ml, in the presence or absence of LH (100 ng/ml), to determine the possible effect of these compounds on progesterone (P4) and ovarian oxytocin (OT) secretion. Only PCB 77 on days 1-5 and 16-18 increased P4 secretion. All PCBs decreased LH-simulated secretion of P4 from luteal cells obtained from all days of luteal phase. Dioxin-like congener (PCB 126) inhibited (P<0.05) the most evidently LH effect on P4 secretion. All congeners, except the lower doses of PCB 126, increased (P<0.05) OT secretion. They can also increase LH-stimulated secretion of OT, but the effect was dependent on the congener used and on the phase of oestrous cycle. On days 1-5 and 10-15, PCB 126 diminished LH-stimulated effect on OT secretion from luteal cells. PCB 77 (mimickig both dioxin and estradiol effect) in the higher doses, amplified effect of LH-stimulated OT secretion, while on all other days it diminished LH influence. PCB 153, which has estrogen-like properties, amplified LH effect on OT secretion during all studied days of the cycle. We conclude that PCBs (supposedly via estrogen and arylhydrocarbon - AhR receptor) may directly affect LH-stimulated function of CL. This does not appear to be a direct adverse effect on luteal steroidogenesis, but rather indirect on OT secretion from or within CL.

17

The protein expression disorders of connexins (Cx26, Cx32 and Cx43) and keratin 8 in bovine placenta under the influence of DDT, DDE and PCBs

54%

Wojciechowska A. , Młynarczuk J. , Kotwica J. , Wojciechowska A. , Młynarczuk J. , Kotwica J.

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tom 21

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nr 4

18

Genomowy i niegenomowy wplyw progesteronu na komorki zenskiego ukladu rozrodczego

51%

Kowalik M. K. , Rekawiecki R. , Kotwica J.

Medycyna Weterynaryjna

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2008

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tom 64

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nr 04B

528-532

EN

Progesterone (P4), which is produced in the corpus luteum, determines the timing of the estrous cycle and pregnancy in many species. The physiological effect of P4 upon target cells is mediated through interaction of this hormone with two specific nuclear progesterone receptor isoforms (PR-A and PR-B), but also through non-genomic mechanisms. The non-genomic action of P4 has been found in the cells of a number of tissues, including in the female reproductive tract. However, the nature of this mechanism is still unknown. It has been determined that P4 can directly affect enzyme activity, nonspecificly change the membrane fluidity which affects receptor stability or it can bind specific membrane receptors for P4, which stimulate early intracellular signaling pathways and initiate the specific cellular response. There are at least three different proteins localized in the cell membrane, which can be a potential membrane progesterone receptor. This paper presents the latest data concerning the intracellular and membrane progesterone receptor and the genomic and non-genomic action of P4 in the female reproductive tract.

19

Expression of progesterone receptor membrane component (PGRMC) 1 and 2, serpine mRNA binding protein 1 (SERBP1) and nuclear progesterone receptor (PGR) in the bovine endometrium during the estrous cycle and the ﬁrst trimester of pregnancy

51%

Kowalik M. K. , Slonina D. , Rekawiecki R. , Kotwica J.

Reproductive Biology

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2013

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tom 13

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nr 1

20

Influence of PGF2a infusion into the anterior uterine vein on progresterone production by ipsilateral and contralateral ovary and LH level in the sows

51%

Kotwica J. , Krzymowski T. , Stefanczyk S. , Ziecik A.

Acta Physiologica Polonica

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1979

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tom 30

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nr 1