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Routine simultaneous production of no-carrier-added high purity 64Cu and 67Ga

100%

Al Rayyes A. H. , Ailouti Y.

tom Vol. 56, No. 4

259-262

A routine production method of no-carrier-added 64Cu was performed. A copper target support is electroplated by gold then an optimized thickness of enriched 68Zn layer is deposited. The 68Zn target was bombarded with a 23.5 MeV and 250 miA proton beam, generating the main nuclear reactions 68Zn(p,2n)67Ga and 68Zn(p,alfa n)64Cu. A semi-automated separation method using a chromatographic column system was developed for 64CuCl2 production. A 600 mCi batch of 64Cu is produced at the end of separation and purification chemistry. The radionuclidic purity of 64Cu was less than 98% as required by the United States and European Pharmacopoeias. Radiochemical purity and activity concentration is suitable for labeling different ligands to produce diagnostic and therapeutic radiopharmaceuticals.

Synthesis and in vivo evaluation of both (2R,3R)-[123I]- and (2S,3S)- -[123I]-trans-2-hydroxy-5-((E)-3-(iodo) allyloxy)-3-(4-phenyl-1-piperazinyl) tetralin as SPECT radiotracer

100%

Assaad T. , Al Rayyes A. H.

2013

tom Vol. 58, No. 2

261--267

We report the synthesis of enantiopure benzovesamicol derivatives: (2R,3R)-[123I]-trans-2-hydroxy-5-((E)-3- -(iodo)allyloxy)-3-(4-phenyl-1-piperazinyl) tetralin and (2S,3S)-[123I]-trans-2-hydroxy-5-((E)-3-(iodo)allyloxy)-3-(4- phenyl-1-piperazinyl) tetralin; [(2R,3R)-[123I]-1 and (2S,3S)-[123I]-1]. Both compounds were obtained with radiochemical and optical purities greater than 97% and with radiochemical yields in the range of 50–60%. To determine whether these compounds could have potential advantage compared to [125I]-iodo benzovesamicol (IBVM), IBVM was also labelled and used as the reference compound in all in vivo experiments. Both (2R,3R)-[123I]-1 and (-)-[125I]-IBVM showed similar time activity curves (TACs) with the highest accumulations in the striatum region followed by the cortex, hippocampus and then cerebellum. While (2S,3S)-[123I]-1 showed an overall homogeneous brain distribution. However, time activity curves of (2R,3R)-[123I]-1 confirmed that this compound could be used to visualize the vesicular acetylcholine transporter (VAChT) in vivo, at each point of the kinetic study. Also (2R,3R)-[123I]-1 showed lower specific bindings compared to [125I]-IBVM. These results suggested that (2R,3R)-[123I]-1 is inferior in comparison with [125I]-IBVM for in vivo VAChT exploration.