Wyniki wyszukiwania - Biblioteka Nauki

1

Effect of darkness on circadian rhythm in the activity of mixed function oxidases system in rats

100%

Plewka A. , Kaminski M.

Acta Neurobiologiae Experimentalis

|

1994

|

tom 54

|

nr S

2

Pinealectomy and pineal hormones modify cytochrome P450-dependent monooxygenase system in rat liver

100%

Plewka A. , Kaminski M.

Polish Journal of Environmental Studies

|

1998

|

tom 07

|

nr 3

EN

The cytochrome P450-dependent liver monooxygenase system is influenced by many endocrine glands. The components of the system show circadian rhythmicity and therefore their activities change during the day. This may suggest that the pineal gland, whose activity is strongly related to the external environment, influences this metabolic system. A growing interest in melatonin used as a nonprescription drug that inhibits aging and cures various diseases prompted us to investigate the influence of pineal hormones on the liver's metabolic system. The aim of this study was to evaluate the effect of pinealectomy, melatonin, or serotonin on the cytochrome P450-dependent monooxygenase system. The experiment was performed on sexually mature male Wistar rats. The rats were divided as follows: a control group, pinealectomized rats, melatonin-treated rats, and seroto- nin-treated rats. Pinealectomy was done 14 days before decapitation. The isolated microsomal fraction was assayed for the activity of cytochrome P450-dependent monooxygenase system and for the activity of the enzymatic system, which non-obligatorily cooperates with the MFO system. Both pinealectomy and prolonged administration of melatonin or serotonin modified the activity of the mixed function oxidase system. In all experimental groups the components of microsome electron-transport chain I were inhibited. In microsome electron-transport chain II only melatonin and serotonin produced an inhibitory effect, while pinealectomy did not affect cytochrome b5 and NADH-cytochrome b5 reductase. 4-Aminopyrine N-deme- thylase and aniline hydroxylase did not alter either after pinealectomy or melatonin treatment (only a decreasing tendency was noted). In contrast, serotonin treatment decreased these activities significantly.

3

Systemy sterowania i zarządzania ruchem

80%

Plewka A. , Okoń T. , Wróblewski T.

Magazyn Autostrady

|

2009

|

tom Nr 5

78--80

PL

Systemy sterowania i zarządzania ruchem są instalowane w największych miastach na świecie. Zostały wdrożone m.in. w dynamicznie rozwijającym się Hongkongu, Melbourne czy Sydney. Z powodu ciągłego rozwoju cywilizacyjnego, a także coraz większej liczby samochodów problemy komunikacyjne są również bolączką wielu miast w Polsce. Pierwszym polskim miastem, w którym wdrożono system sterowania ruchem SCATS, był Rzeszów. Aktualnie rozwiązanie to funkcjonuje m.in. w Gdyni, Olsztynie i Łodzi.

EN

The Control and Traffic Management Systems are installed in all major cities in the world. They have been implemented, for e.g. in booming Hong Kong, Melbourne and Sydney. Due to the permanent development of civilization, as well as an increasing number of cars, also many Polish cities face traffic problems. Rzeszów was the first Polish city where SCATS Traffic Control System was implemented. At present, the system works in such cities as Gdynia, Olsztyn and Łódź.

4

Investigations of circadian rhythm of Zn++ in rats liver, kidney and gonads

80%

Pawlicki K. , Kaminski M. , Plewka A.

Acta Biologica Cracoviensia. Series Zoologia

|

1991

|

tom 33

5

Technologia odzyskiwania srebra, miedzi i innych metali w postaci nanoproszków z odpadów flotacyjnych i elektrolitów odpadowych przemysłu miedziowego

80%

Łoś P. , Łukomska A. , Plewka A. , Wilson-Polit D.

Cuprum : czasopismo naukowo-techniczne górnictwa rud

|

2009

|

tom nr 1, 2

60-74

PL

W niniejszej pracy przedstawiono wyniki badań mających na celu opracowanie technologii produkcji in situ (metodami hydrometalurgicznymi i elektrochemicznymi) nanoproszków z elektrolitów odpadowych przemysłu miedziowego. Potencjalnym surowcem do produkcji nanoproszków są odpady flotacyjne KGHM Polska Miedź SA, roztwory odpadowe po elektrorafinacji miedzi oraz z procesów galwanizacji, które mogą zawierać od kilku do kilkuset (µg/kg metali takich jak Cd, Hg, Pb, Cu, Ag, Co, Ni, Zn i innych. Prezentowana metoda otrzymywania nanoproszków metali w skali przemysłowej z elektrolitów odpadowych oparta jest na elektrolizie impulsowej i dlatego jest stosunkowo prosta i komercyjnie bardzo opłacalna. Metodą tą otrzymano nanoproszki miedzi i srebra o czystości do 99,999%.

EN

In this paper we present the results concerning the development of the in situ manufacturing technologies of nanopowders by hydrometallurgical and electrochemical methods. The potential raw material is the wastewater which is a byproduct of the ore flotation process. Chemical analysis of the tailings revealed that a series of metals such as: Cd, Hg, Pb, Cu, Ag, Co, Ni, Hf, Nb, Os, Re, Rh, Sc, Th, V, W, Zn, Zr etc. are contained in solid and liquid fraction. The presented method based on pulse electrolysis from aqueous solution is cost effective and enables commercial manufacturing of copper and silver nanopowders of chemical purity up to 99,999%.

6

Ischemia-reperfusion injury of the liver: role of some factors

80%

Plewka A. , Rutkowski T. , Kaminski M.

|

2000

|

tom 08

|

nr 2

7

Study on ischemic-reperfusion damage to the liver: hitherto existing successes and defeats

80%

Rutkowski T. , Plewka A. , Kaminski M.

|

2000

|

tom 08

|

nr 1

8

Effect of microsomal monooxygenases inductors of hepatic Mg plus2-adenosine triphosphatase and acid phosphatase activities in aging rats

80%

Plewka A. , Plewka D. , Nowaczyk G. , Kaminski M.

Acta Toxicologica

|

2005

|

tom 13

|

nr 1

9

Animals manifested the influence of age and some inducers on glucose-6-phosphate dehydrogenase activity

80%

Plewka A. , Plewka D. , Ihnatowicz J.

Acta Toxicologica

|

2006

|

tom 14

|

nr 1-2

10

Influence of age on picture of rat damage induced by chlorfenvinphos

80%

Kaminski M. , Bienkowska M. , Plewka A. , Kaszuba M.

Acta Poloniae Toxicologica

|

1996

|

tom 04

|

nr 1

11

The constituents of hepatic and placental mixed function oxidase [MFO] systems after acute carbon tetrachloride intoxication

80%

Bienioszek M. , Plewka A. , Chmielarska-Kotus K. , Pajak J.

Polish Journal of Environmental Studies

|

1995

|

tom 04

|

nr 2

EN

The influence of acute carbon tetrachloride intoxication on hepatic and placental cytochrome P-450 content, and on NADPH-cytochrome P-450 reductase was examined in Wistar female rats. The animals were pretreated with a single dose of CC14 before pregnancy. The contents of the constituents of the MFO system were measured at term. The results revealed that the CCl4-mediated decrease at the total hepatic cytochrome P-450 level was reduced by pregnancy. Carbon tetrachloride pretreatment did not change the placental cytochrome P-450 level. A significant increase in placental microsomal cytochrome P-450 reductase activity was found after acute CC14 intoxication, which did not influence this enzyme in the liver of pregnant individuals.

12

Circadian variation of mitochondrial succinic dehydrogenase and microsomal cytochrome P-450 dependent monooxygenase activity in the liver of sexually immature and mature rats

80%

Wielgus-Serafinska E. , Plewka A. , Kaminski M.

Journal of Physiology and Pharmacology

|

1993

|

tom 44

|

nr 2

13

Morphological, histochemical and biochemical evaluation of influence of two-component contraceptive drugs on liver

71%

Maicher A. , Kaminski M. , Plewka A. , Jochemczyk U. , Siekierska E.

|

tom 06

|

nr 1

89-106

14

Effects of coal dusts with different concentrations of metals on structure, hepatocellular enzymatic markers, and cytochrome P-450-dependent monooxygenase system in rat liver

70%

Trzeciak H. I. , Kaminski M. , Plewka A. , Malecki A. , Gabryel B.

Polish Journal of Environmental Studies

|

1996

|

tom 05

|

nr 1

EN

For three months rat livers absorbed coal dust containing low or high concentrations of heavy metals. We found that these concentrations of heavy metals significantly decrease cytochrome P-450 content in hepatic microsomes, and that this decrease correlates with the concentration of heavy metals. Furthermore, we have shown that only coal dust with high heavy metal content produces such structural lesions as necrosis and apoptosis in zone III of the acinus. These lesions are accompanied by increased intracellular catabolism (acid phosphatase), and by considerably decreased activities of enzymes, which are markers of energy production (succinate and lactate dehydrogenase), glycogen metabolism (gluco- se-6-phosphatase), and active excretion of metabolites into bile (adenosine triphosphatase stimulated by Mg++).

15

Effect of coal dusts containing heavy metals on structure, cellular enzymatic markers, and cytochrome P-450-dependent monooxygenase system in rat kidney

70%

Trzeciak H. I. , Kaminski M. , Plewka A. , Malecki A. , Pudelko A.

|

nr 2

EN

We evaluated morphological changes, the activities of succinate dehydrogenase, lactate dehydrogenase, glucose-6-phosphatase, Mg2+ -dependent adenosine triphosphatase, and acid phosphatase, and the activity of the cytochrome P-450-dependent monooxygenase system in the kidneys of rats exposed to coal dusts containing either very low or high amounts of heavy metals. We showed that the coal dust with a very low content of heavy metals (VLCHM) did not produce any structural lesions, but increased significantly the activities of the enzymes. These changes probably reflected kidney adaptation to the unfavorable conditions caused by the metals. The interactions among them reduced the eventual nephrotoxic effect of their action. The coal dust with a high content of heavy metals (HCHM) damaged proximal convoluted tubules, straight tubules, and, to a lesser degree, distal convoluted tubules, especially those of long-looped nephrones. The levels and the activities of the assayed cytochromes decreased significantly in the kidneys of rats exposed to HCHM coal dust.

16

Effect of coal dusts containing heavy metals on the structure, cellular enzymatic markers, and cytochrome P-450-dependent monooxygenase system in rat kidneys

70%

Trzeciak H. I. , Kaminski M. , Plewka A. , Malecki A. , Pudelko A.

Polish Journal of Environmental Studies

|

1995

|

tom 04

|

nr 4

EN

We evaluated morphological changes, the activities of succinate dehydrogenase, lactate dehydrogenase, glucoso-6-phosphatase, Mg2+-dependent adenosine triphosphatase, and acid phosphatase, and the activity of the cytochrome P-450-dependent monooxygenase system in rat kidneys exposed to coal dusts containing either low or high amounts of heavy metals. We showed that the coal dust with a very low content of heavy metals (VLCHM) did not produce any structural lesions, but significantly increased the activities of the enzymes. These changes probably reflected kidney adaptation to unfavorable conditions caused by the metals. The interactions among them reduced the eventual nephrotoxic effect of their action. The coal dust with high content of heavy metals (HCHM) damaged proximal convoluted tubules, straight tubules, and, to a lesser degree, distal convoluted tubules, especially those of long-looped nephrones. The levels and the activities of the assayed cytochromes decreased significantly in the kidneys of rats exposed to HCHM coal dust.

17

Metabolic interactions between acetylsalicylic acid, xylene and trichloroethylene in rats

70%

Zielinska-Psuja B. , Orlowski J. , Plewka A. , Kaminski M. , Kowalowka-Zawieja J.

Polish Journal of Environmental Studies

|

2001

|

tom 10

|

nr 1

EN

This study aimed at evaluating the effect of acetylsalicylic acid (ASA) (150 and 300 mg/kg b.w.) on urinary trichloroethanol and trichloroacetic acid excretion and the liver cytochrome P-450-dependent monooxygenase system (MFO) in rats treated with trichloroethylene (TRI) alone or with xylene (XYL) at a concentration of 4.5 mmol/m3 air. The study has shown that xylene equally decreased trichloroacetic acid and trichloroethanol excretion within 48 hours after exposure. Acetylsalicylic acid diminished the excretion of both trichloroethylene metabolites in a dose-dependent manner, although the effect was weaker than that of xylene.Liver cytochrome P-450 content tended to increase after both doses of ASA. There were no significant changes in cytochrome b5 content and the activities of NADPH-cytochrome P-450 and NADH-cytochrome b5 reductases. TRI decreased cytochrome P-450 and cytochrome b5 contents and reduced both reductase activities. XYL induced all MFO components. Acetylsalicylic acid at 150 mg/kg combined with TRI inhalation tended to lower cytochrome b5 content and NADH-cytochrome b5 reductase activity. When given at 300 mg/kg, ASA increased cytochrome P-450 content, while cytochrome b5 content and NADH-cytochrome b5 reductase activity were still decreased, but to a smaller degree when compared with the lower ASA dose. XYL together with the lower dose of ASA induced the MFO system. Exposure to XYL and the higher dose of ASA elevated cytochrome P-450 content and NADPH-cytochrome P-450 reductase activity and it diminished NADH-cytochrome b5 reductase activity. In rats treated simultaneously with ASA, XYL and TRI both cytochromes increased in amount, while the other components of the MFO system did not change.

18

Effect of ozonetherapy on structural patterns of selected rat organs in endotoxemic shock

61%

Madej P. , Plewka A. , Madej J. A. , Kuryszko J. , Plewka D. , Szczepanik T. , Kaminski M.

Acta Toxicologica

|

2007

|

tom 15

|

nr 2

95-105

19

Effect of toluene and ethanol on trichloroethylene metabolism in rat liver

61%

Orlowski J. , Zielinska-Psuja B. , Plewka A. , Kaminski M. , Kowalowka J. , Dobrogowska J. , Rutkowski T.

|

tom 06

|

nr 1

55-65

20

Effect of long-term cadmium treatment on apoptosis and proliferation of rat kidney cells

61%

Plewka D. , Nowaczyk G. , Plewka A. , Brzoska M. M. , Szczepanik T. , Moniuszko-Jakoniuk J.

Acta Toxicologica

|

2007

|

tom 15

|

nr 2

141-148