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Induced sputum metalloproteinases and their inhibitors in relation to exhaled nitrogen oxide and sputum nitric oxides and other inflammatory cytokines in patients with chronic obstructive pulmonary disease

100%

Ziora D. , Dworniczak S. , Kozielski J.

Journal of Physiology and Pharmacology. Supplement

2008

tom 59

nr 6

809-817

Chemiluminescence in activated murine macrophage J774.2 cells modulated by flavones

100%

Krol W. , Czuba Z. P. , Pietsz G. , Dworniczak S.

Folia Histochemica et Cytobiologica. Supplement

1997

tom 35

nr 2

Late consequences of respiratory system burns

75%

Krzywiecki A. , Ziora D. , Niepsuj G. , Jastrzebski D. , Dworniczak S. , Kozielski J.

2007

tom 58

nr 5

Human cytomegalovirus DNA level in patients with idiopathic pulmonary fibrosis

63%

Dworniczak S. , Ziora D. , Kapral M. , Mazurek U. , Niepsuj G. , Rauer R. , Wilczok T. , Kozielski J.

nr 3

67-75

The objectives of the study were to estimate human cytomegalovirus (HCMV) DNA copy number in broncho-alveolar lavage cells, blood leukocytes, and serum of patients with idiopathic pulmonary fibrosis (IPF). The study groups consisted of 16 patients, newly diagnosed with IPF and never treated, (mean age 40.9 ±11.0 yr; F/M-7/9) and in 16 adult healthy volunteers (mean age 36.8 ±6.4 yr; F/M-4/12) used as controls. The HCMV DNA copy number was calculated by a Q-PCR method using TaqMan ABI PRISMTM7700. We found that the prevalence of the HCMV DNA positive subjects in the patient group (75%) did not differ significantly from that in the control group (69%). We also found that in both patient and control groups the mean HCMV DNA copy number in BAL cells was significantly higher than that in blood leukocytes (log10=2.7 vs. 1.2 for patients and 2.8 vs. 0.9 for controls, respectively). However, a higher HCMV DNA copy number in blood serum was observed in IPF patients than in controls (log10=3.2 vs. 2.0, respectively). We conclude that the lungs play an important role in the human pathobiology of cytomegalovirus sustenance.

Występowanie lekoopornych szczepów Mycobacterium sp. na terenie woj. śląskiego w latach 2000-2001

63%

Wojtyczka R. D. , Dworniczak S. , Pacha J. , Idzik D. , Kepa M. , Wydmuch Z. , Glab S. , Oklek K. , Kozielski J.

Diagnostyka Laboratoryjna

2002

tom 38

nr 3

Spirometric parameters in malnourished girls with anorexia nervosa

63%

Ziora K. , Ziora D. , Oswiecimska J. , Roczniak W. , Machura E. , Dworniczak S. , Tomalak W. , Dyduch A.

Journal of Physiology and Pharmacology. Supplement

2008

tom 59

nr 6

801-807

PCR-RFLP analysis of a point mutation in codons 315 and 463 of the katG gene of Mycobacterium tuberculosis isolated from patients in Silesia, Poland

63%

Wojtyczka R. D. , Dworniczak S. , Pacha J. , Idzik D. , Kepa M. , Wydmuch Z. , Glab S. , Bajorek M. , Oklek K. , Kozielski J.

Polish Journal of Microbiology

2004

tom 53

nr 2

Resistance to antituberculous agents is an important cause of ineffectiveness of antimicrobial therapy. The resistance of M. tuberculosis to antituberculous agents is a result of mutations in genes participating in those agent's action. The antituberculous drug - isoniazid can be activated by Mycobacterium tuberculosis either through a hydroperoxidase I/II or a superoxide-dependent oxyferrous pathway. The present study analyzed the frequency of the mutations occurring in codons 315 and 463 in katG gene of Mycobacterium tuberculosis strains, isolated from patients with pulmonary tuberculosis from Silesia, Poland. In this study 23 isoniazid-resistant Mycobacterium tuberculosis strains were analyzed. For RFLP analysis, a 620 bp amplified fragment of katG gene was digested with restriction endonuclease Mspl. Among 24 isoniazid-resistant strains, isolated from patients between 2000-2001, point mutations were found in 30% of analyzed isoniazid-resistant strains in codons 315 or 463 (7 strains). In contrast, no mutations in codons 315 and/or 463 katG gene were found in 16 strains (70%). Obtained results suggests that point mutations S315T (AGC—>ACC) and R463L in katG gene are infrequent in the analyzed population.