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Deep brain stimulation in generalized dystonia

100%

Mandat T. , Koziara H. , Nauman P. , Bonicki W.

2011

tom Vol. 31, no. 3

57-63

Eleven patients with diagnosed generalized dystonia (GD) were treated with deep brain stimulation (DBS). The clinical status of the patients was evaluated and recorded pre- and post-operatively. The target globus pallidus or subthalamic nucleus was identified with direct and indirect methods and confirmed electrophysiologically in the operating room. All eleven patients reported subjective improvement following the surgery what was confirmed using scales tailored for the group. The improvement lasted from 10 months to 40 months. DBS can be effectively and safely utilized to alleviate symptoms of generalized dystonia in selected patients.

Subthalamic nucleus deep brain stimulation in Parkinson's disease

88%

Mandat T. , Koziara H. , Nauman P. , Tykocki T. , Bonicki W.

2011

tom Vol. 31, no. 3

47-55

A group of 37 patients diagnosed with Parkinson's disease (PD) were treated with subthalamic deep brain stimulation (STN DBS). The mean age at implantation was 59 - 11 years and PD has been present from 6 to 17 years (mean 9). The STN was identified by direct and indirect methods: macro stimulation and microrecording in all cases. At a three month follow-up, the authors observed a mean reduction of 49% in UPDRS II score and a mean reduction of 65% in UPDRS III score. Mean reduction of 1-dopa consumption was 62%. The authors concluded that STN DBS safely reduces disabling symptoms of PD.

DNA hypermethylation DNA repair genes in neurological tumours

75%

Bujko M. , Kober P. , Koscik A. , Nauman P. , Bonicki W. , Siedlecki A.

tom 53

nr Supplement 1