Wyniki wyszukiwania - Biblioteka Nauki

1

Biochemical and medical importance of vanadium compounds

100%

Korbecki J. , Baranowska-Bosiacka I. , Gutowska I. , Chlubek D.

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nr 2

EN

Vanadium belongs to the group of transition metals and is present in the air and soil contaminants in large urban agglomerations due to combustion of fossil fuels. It forms numerous inorganic compounds (vanadyl sulfate, sodium metavanadate, sodium orthovanadate, vanadium pentoxide) as well as complexes with organic compounds (BMOV, BEOV, METVAN). Depending on the research model, vanadium compounds exhibit antitumor or carcinogenic properties. Vanadium compounds generate ROS as a result of Fenton's reaction or of the reaction with atmospheric oxygen. They inactivate the Cdc25B2 phosphatase and lead to degradation of Cdc25C, which induces G2/M phase arrest. In cells, vanadium compounds activate numerous signaling pathways and transcription factors, including PI3K-PKB/Akt-mTOR, NF-κB, MEK1/2-ERK, that cause cell survival or increased expression and release of VEGF. Vanadium compounds inhibit p53-dependent apoptosis and promote entry into the S phase of cells containing functional p53 protein. In addition, vanadium compounds, in particular organic derivatives, have insulin-mimetic and antidiabetic properties. Vanadium compounds lower blood glucose levels in animals and in clinical trials. They also inhibit the activity of protein tyrosine phosphatase 1B. By activating the PI3K-PKB/Akt pathway, vanadium compaunds increase the cellular uptake of glucose by the GLUT4 transporter. The PKB/Akt pathway is also used to inactivate glycogen synthase kinase-3. The impact of vanadium compounds on inflammatory reactions has not been fully studied. Vanadium pentoxide causes expression of COX-2 and the release of proinflammatory cytokines in a human lung fibroblast model. Other vanadium compounds activate NF-κB in macrophages by activating IKKβ.

2

Comparative research concerning behavior of GDP and AlF3 in vacuum and in water environments using molecular modeling

100%

Machory Z. , Gutowska I. , Straszko J. , Machalinski B.

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nr Supplement 1

3

The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid

100%

Korbecki J. , Baranowska-Bosiacka I. , Gutowska I. , Chlubek D.

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nr 4

4

Effect of zinc supplementation on the distribution of lead in tissues of rats intoxicated by lead compounds

75%

Baranowska-Bosiacka I. , Gutowska I. , Skibicka E. , Sobieniecki A. , Stanczyk-Dunaj M. , Skotnicka E. , Chlubek D.

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tom 20

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nr 1

EN

The permissible threshold level of lead in blood (Pb-B) is currently established at 5 mg dL-1, but evidence suggests that it is impossible to determine the safety threshold for lead (Pb) and any exposure, especially in children, must be considered as potentially harmful. Methods used to reduce the concentration of Pb in blood (e.g. EDTA, penicillamine) are not always effective and are associated with serious side effects. One of the proposed dietary supplements in the case of exposure to Pb and low blood Pb concentrations is zinc (Zn), but the published literature on its effectiveness is limited. Therefore, the aim of this study was to clarify whether Zn supplementation may help reduce the concentration of Pb in the blood and tissues of rats, at the Pb-B level previously recognized as safe. Tests were performed on 6-8 week old male Wistar rats. Rats were divided into control and experimental groups: Group C – rats receiving drinking water ad libitum for 4 weeks; Group Pb – rats receiving Pb acetate 0.1% (PbAc) in drinking water ad libitum for 4 weeks; Group Zn – rats receiving ZnCO3 300 mg kg-1 diet for 4 weeks; Group Pb+Zn – rats receiving PbAc in drinking water ad libitum plus 300 mg ZnCO3 kg-1 diet for 4 weeks. The applied dose of 300 mg of ZnCO3 kg-1 diet results in a high but non-toxic Zn level. The concentrations of Pb and Zn in blood, plasma, liver and bone were determined by emission spectrometry in inductively coupled argon plasma (ICP OES). Incidental exposure of adult rats to Pb at doses resulting in the level of Pb in blood below the previously recognized as safe one caused: (i) increased Pb concentration in the bones and plasma and its reduction in the whole blood and liver (ii) simultaneous supplementation of rats exposed to Pb with a high but non-toxic dose of zinc did not result in the reduction of the Pb concentration in the blood and tissues of rats, nor did it induce any changes in the distribution of Pb in the examined tissues (iii) supplementation of diets with a high but non-toxic dose of Zn is not an effective method of reducing the concentration of Pb in blood at Pb-B previously recognized as safe. However, the therapy consisting of zinc supplementation to support the action of chelators could be crucial for the elimination of Pb from the body.

5

Biomonitoring of lead and fluoride contamination in forests using chemical analysis of hard tissues of roe deer (Capreolus capreolus L.)

75%

Sobota S. , Baranowska-Bosiacka I. , Gutowska I. , Kupiec M. , Dusza E. , Machoy Z. , Chlubek D.

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nr 2

EN

Our study assesses environmental lead and fluoride pollution in West Pomeranian forests in Poland, on the basis of chemical analysis of antlers and skull bones of roe deer (Capreolus capreolus L.) from the surroundings of Szczecin and Drawsko Pomorskie, Poland. Lead was measured by atomic absorption spectrometry, and fluorides by using an ion-selective electrode. Our study indicates greater lead contamination in the forests near Drawsko Pomorskie than in the forests near Szczecin. The cause may be their long-term exploitation as a military area. The roe deer population near Szczecin is exposed to increased fluoride pollution, but the concentration of fluoride in hard tissues of roe deer has diminished considerably in comparison with data acollected 10 years prior to our study.

6

Arachidonic acid contained in triacylglycerol is a potential factor determining phagocytic function of human monocytes/macrophages

75%

Gutowska I. , Stachowska E. , Baskiewicz-Masiuk M. , Kijowski J. , Dziedziejko V.-E. , Machalinski B.-B. , Chlubek D.

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nr Supplement 4

7

Conjugated linoleic acids diminish glycogen synthase and glycogen synthase kinase-3 expression in muscle cells of C57BL/6J mice - in vitro and in vivo study

63%

Szynkowska A. , Siwiec E. , Gutowska I. , Baranowska-Bosiacka I. , Szczuko M. , Kotlega D. , Marlicz W. , Stachowska E.

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tom 70

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nr 6

8

Hymenolepis diminuta - caused inflammation via the increased expression and activity of COX-1 and COX-2 in the rat jejunum and colon

63%

Kosik-Bogacka D. , Baranowska-Bosiacka I. , Kolasa-Wolosiuk A. , Lanocha-Arendarczyk N. , Gutowska I. , Korbecki J. , Namieta H. , Rotter I.

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nr Suppl.

9

The short chain fatty acids and lipopolysaccharides status in sprague-dawley rats fed with high-fat and high-cholesterol diet

63%

Maciejewska D. , Skonieczna-Zydecka K. , Lukomska A. , Gutowska I. , Dec K. , Kupnicka P. , Palma J. , Pilutin A. , Marlicz W. , Stachowska E.

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tom 69

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nr 2

10

The fatty acids content in popular bars

63%

Wiercioch M. , Szelag-Pieniek S. , Peszko K. , Baranowska-Bosiacka I. , Maciejewska D. , Lukomska A. , Dec K. , Janda K. , Chlubek D. , Gutowska I.

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2018

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tom 33

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nr 4

EN

In view of the significance of qualitative fatty acid profile, the aim of this research was to determine and compare the content of fatty acids in two groups popular snacks which were classified into two product groups: healthy or unhealthy. Gas chromatograph was used to analyze the fatty acid profile. The study showed that the products classified as ‘unhealthy’ generally contained more fatty acids than ‘dietary’ products. They also had a higher content of fatty acids with atherogenic properties. Approx. 66% of fatty acids in both groups were long-chain fatty acids (LCFAs), followed by cis monounsaturated fatty acids (MUFAs) which accounted for 25% of all FAs. In contrast, very long chain fatty acids (VLCFAs) were present in small quantities. We also found quite large amounts of linoleic acid (PUFA), which accounted for 2.6% to 18.5% of the total composition of the snacks and appeared in all samples

PL

Celem pracy była analiza i porównanie zawartości kwasów tłuszczowych w popularnych batonikach, które podzielono na dwie grupy – batoniki „zdrowe” i „niezdrowe”. Analizę przeprowadzono metodą chromatografii gazowej. Wykazano, że produkty oznaczone jako „niezdrowe” ogólnie zawierają znacznie większą ilość kwasów tłuszczowych w porównaniu z produktami oznaczonymi jako „zdrowe”. Dodatkowo zawierają znacznie więcej kwasów tłuszczowych wykazujących właściwości aterogenne. Przeważającą część (ok. 66%) wszystkich kwasów tłuszczowych w obu badanych grupach stanowiły kwasy nasycone długołańcuchowe (LCFA), podczas gdy cis jednonienasycone kwasy (MUFA) stanowiły ok. 25% całej puli kwasów. Z kolei długołańcuchowe kwasy tłuszczowe (VLCFA) były obecne w badanych produktach w niewielkich ilościach. W badaniach wykazano, że analizowane produkty zawierały także dość duże ilości kwasu linolowego (PUFA), który stanowił od 2,6% do 18,5% całkowitego składu przekąsek i występował we wszystkich próbkach