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EN
The purpose of this study is to evaluate the effectiveness of functional neuromarker- based electroencephalographic training with neurofeedback (EEG-NFB) for a patient with dysexecutive syndrome following neurosurgical operation of two brain aneurysms of the left and right middle cerebral artery (MCA) detected after COVID-19 disease. A right-handed, 56-years-old, not vaccinated, patient, became infected with SARS- CoV-2 and contracted COVID-19 with the manifestation of respiratory symptoms, high fever, dyspnea and low saturation of 79% Sa02. She was hospitalized at the Infectious Disease Unit, where a positive RT PCR test for COVID-19 was confirmed. The acute phase of COVID-19, during which oxygen therapy was administered, lasted two weeks and was complicated by brain fog and transient hypertension (175/100). There were no signs of focal damage to the central nervous system. She was discharged home in a good general and neurological condition. After returning home, the patient was unable to cope with daily functioning, as she said her brain fog continued to persist, manifesting itself as executive dysfunction. Eight weeks after the infection, the patient's neuropsychiatric condition worsened. On CT and MRI examination of the cerebral vessels, she was diagnosed with the presence of two aneurysms located on the left and right middle cerebral arteries (MCA). She was operated on at the Department of Neurosurgery and Neurotraumatology, where a pterional craniotomy and clipping of both brain aneurysms was performed. The Yasargil titanium clip was placed on the aneurysm neck. During the surgery procedures, performed two months apart, there were no signs of a history of subarachnoid haemorrhage and the post-operative period was uneventful, except for a drooping right-eye eyelid (after the second surgery) with a tendency to improve. Each time, the patient was mobilized and walked independently and was discharged home in a good general condition, with no neurological symptoms, except for executive dysfunction. Approximately five months after the SARS-CoV-2 infection (four weeks after the second surgery), her executive dysfunction worsened. Neuropsychological testing using Mindstreams™ Interaction Computer Tests revealed moderate Dysexecutive Syndrome (DES), while neurophysiological testing using qEEGs, ERPs and sLORETA tomography, a functional neuromarker of frontotemporal area dysfunction. The EEG pattern was characterized by excessive, slow (about 6 Hz) activity in frontotemporal areas, which indicated the progressive loss of cognitive control over time. The patient was offered an electroencephalographic training protocol with neurofeedback (EEG-NFB) based on the detected functional neuromarker, which reduced DES. The improvement achieved during therapy was statistically significant [compared to the normative database (Human Brain Index, HBI)]. In effect, the patient's quality of life improved, as she herself pointed out. Her symptoms of brain fog and DES disappeared and she returned to her previous work as a waitress. The Human Brain Index (HBI) methodology can be successfully used in the neurodiagnosis and implementation of individualized electroencephalographic training with neurofeedback (EEG-NFT) for patients with executive dysfunction after contracting longCOVID.
EN
One of the key parameters in the evaluation of disorders of consciousness (DOC) is visual behavior. In the past, visual potential testing or PET scanning was mainly used to assess these parameters. Recently, Eye Tracker (ET) technology for assessing visual functions has emerged; however, there are only a few publications devoted to the use of this technology in assessing people with disorders of consciousness (DOC). The purpose of this study was to evaluate the feasibility of using ET in the diagnosis of visual functioning in DOC patients. The study group consisted 25 patients (8 women and 17 men) awakened from prolonged post-traumatic coma in the Care and Treatment Facility of the "Light" Foundation in Toruń. The coma occurred as a result of severe brain damage: brain injury, stroke or sudden cardiac arrest. The mean age was 39.83 (SD 11.88) for the entire group, 38.85 (SD 9.99) for women, and 40.23 (SD 12.84) for men. All of these patients were in various states of disorders of consciousness (DOC), which was examined using the Coma Recovery Scale-Revised (CRS-R) (Giaciano et al., 2004). Appropriate inclusion and exclusion criteria were applied based on examinations by an internal medical physician and an ophthalmologist. Important exclusion criteria from the study were infection, elevated temperature, visual impairment and patient agitation. The visual functioning of the patients was measured with the use of the Eye Tracker Tobii X-120 device. A significant difference in visual functioning was demonstrated primarily in the areas of (1) reaction time to first fixation, where the Minimal Consciousness State minus (MCS-) group showed a significantly longer reaction time compared to the Minimal Consciousness State plus (MCS+) and the Emergency of Minimal Consciousness State (EMCS) groups; (2) fixation duration, where the MCS- group showed a longer time compared to patients in the MCS+ and EMCS groups; (3) the number of fixation points on the screen, where the MCS- group showed a significantly lower number of fixation points compared to the MCS+ and EMCS groups. Eye Tracker Tobii X-120 can serve as a valuable tool to aid in the neuropsychological diagnosis of individuals experiencing states of reduced consciousness. Indicators that most differentiate between the different levels of impaired consciousness include the time to the first fixation, the number of fixation points on the screen and the total number of fixations.
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