We present a description of evolution of time-resolved systems developed at the Department of Physics, Politecnico di Milano for tissue oximetry and functional brain imaging. From a single source and 4-channel set-up we have upgraded to a potentially 18-sources and 64-channel device. An example of sensitivity of the latest set-up is reported for a motor task experiment. A short discussion on the next generation time-resolved instrumentation for functional studies is also presented.
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