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Melanin synthesis in microorganisms - biotechnological and medical aspects

100%

Plonka P. M. , Grabacka M.

Acta Biochimica Polonica

2006

tom 53

nr 3

Phytases and myo-inositol modulate performance, bone mineralization and alter lipid fractions in the serum of broilers

61%

Zyla K. , Dulinski R. , Pierzchalska M. , Grabacka M. , Jozefiak D. , Swiatkiewicz S.

Journal of Animal and Feed Sciences

2013

tom 22

nr 1

Under conditions simulating intestinal digestion in broilers, phytase B was found to free myo-inositol from low non-phytate phosphorus maize–soyabean meal-based and wheat–soyabean meal-based diets, whereas both 3- and 6-phytases A accelerated myo-inositol release only in the presence of phytase B. In the feeding experiment, myo-inositol at 1 g · kg–1 increased the feed intake and body weight gain of broilers fed both types of feeds. Phytase B at 1300 acid phosphatase units (AcPU) · kg–1 enhanced feed consumption, body weight gain, and tibia mineralization, whereas phytase B mixed with 6-phytase A at 500 phytase units (FTU) · kg–1 produced further enhancements in performance and bone mineralization. After 6 weeks, broilers fed the maize-based diets supplemented with both phytase B and 6-phytase A had increased serum concentrations of triglycerides and HDL-cholesterol, as well as an enhanced HDL/total cholesterol ratio. The increases in this ratio cannot be attributed to the release of phosphorus or to the generation of myoinositol by the supplemented enzymes, but can only be explained as effects of intermediate products of phytate dephosphorylation.

Fenofibrate subcellular distribution as a rationale for the intracranial delivery through biodegradable carrier

41%

Grabacka M. , Waligorski P. , Zapata A. , Blake D. A. , Wyczechowska D. , Wilk A. , Rutkowska M. , Vashistha H. , Ayyala R. , Ponnusamy T. , John V. T. , Culicchia F. , Wisniewska-Becker A. , Reiss K.

Journal of Physiology and Pharmacology

2015

tom 66

nr 2