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Myiosis gałki ocznej u dziecka wywołana przez larwę Hypoderma bovis (de Geer)

100%

Zukowski K. , Krukowska K.

Wiadomości Parazytologiczne

1965

tom 11

nr 5

A specimen of an unidentified parasite was taken out of the eye ball of an 8-year-old boy hospitalized in April 1964. A detailed analysis of the parasite showed that in was the Ist larval stage of Hypoderma bovis. The conservative treatment was unsuccessful and the eye ball, largely domaged by the parasite, had to be removed.

Optymalizacja warunków enzymatycznej hydrolizy celulozy prowadzonej przy udziale preparatu celulolitycznego z hodowli Fusarium sp.

80%

Podgorska E. , Bujak S. , Krukowska K.

Annales Universitatis Mariae Curie-Skłodowska. Sectio E. Agricultura

1982

tom 37

Lysosomal high molecular weight multienzyme complex

70%

Ostrowska H. , Krukowska K. , Kalinowska J. , Orlowska M. , Lengiewicz I.

Cellular and Molecular Biology Letters

2003

tom 08

nr 1

Three acidic glycosidases: β-galactosidase (β-GAL, EC 3.2.1.23), α-neuraminidase (NEUR, sialidase, EC 3.2.1.18), N-acetylaminogalacto-6-sulfate sulfatase (GALNS, EC 3.1.6.4) and serine carboxypepidase cathepsin A (EC 3.4.16.1) form a functional high molecular weight complex in the lysosomes. The major constituent of this complex is cathepsin A, the so-called “lysosomal protective protein” (PPCA). By forming a multienzyme complex, it protects the glycosidases from rapid intralysosomal proteolysis, and it is also required for the intracellular sorting and proteolytic processing of their precursors. In man, a deficiency of cathepsin A leads to a combined deficiency of β-GAL and NEUR activities, called “galactosialidosis”. Multiple mutations identified in the cathepsin A gene are the molecular basis of this lysosomal storage disease. This review describes the structural organization of the lysosomal high molecular weight multienzyme complex and the importance of the protective protein/cathepsin A in physiology and pathology.

Coincidence between spontaneous release of interferon and tumor necrosis factor by colostral leukocytes and the production of a colostrinine by human mammary gland after normal delivery

61%

Piasecki E. , Inglot A. D. , Winiarska M. , Krukowska K. , Janusz M. , Lisowski J.

Archivum Immunologiae et Therapiae Experimentalis

1997

tom 45

nr 1

Colostrinin: a proline-rich polypeptide [PRP] complex isolated from ovine colostrum for treatment of Alzheimer's disease. A double-blind, placebo-controlled study

61%

Leszek J. , Inglot A. D. , Janusz M. , Lisowski J. , Krukowska K. , Georgiades J. A.

Archivum Immunologiae et Therapiae Experimentalis

1999

tom 47

nr 6

Cyclic analogues of proline-rich protein fragments. Part 1. Synthesis and evaluation of immunotropic activity

51%

Wirkus-Romanowska I. , Ciurak M. , Miecznikowska H. , Rolka K. , Janusz M. , Szymaniec S. , Krukowska K. , Lisowski J. , Kupryszewski G.

Polish Journal of Chemistry

1998

tom Vol. 72, nr 11

2394-2398

Proline-rich protein (PRP), isolated from ovine colostrum, possesses strong immunotropic activity. The nonapeptide (Val-Glu-Ser-Tyr-Val-Pro-Leu-Phe-Pro) and the hexapeptide (Tyr-Val-Pro-Leu-Phe-Pro) PRP fragments reveled biological activity similar to that of the native protein. Seeking for analogues of PRP fragments with costrained structure, two cyclic peptides were synthesized by the solid phase method: Cys-Val-Glu-Ser-Tyr-Val-Pro-Leu-Phe-Pro-Cys and Ac-Glu-Tyr-Val-Pro-Leu-Phe-Pro-Lys-NH2. Immunotropic activity of both peptides in murine system was the same as for linear nonapeptide, whereas all three peptides were practically inactive in human system, where resistance to hydrocortisone and induction of two cytokinins IFN and TNF were used as indicators, respectively.