PL
 |
EN
Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl
Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 9

Liczba wyników na stronie
first rewind previous Strona / 1 next fast forward last
Wyniki wyszukiwania
help Sortuj według:

help Ogranicz wyniki do:
first rewind previous Strona / 1 next fast forward last
1
Content available remote The effect of 5-(n-alk(en)ylresorcinols on membranes. I. Characterization of the permeability increase induced by 5-(n-heptadecenyl) resorcinol
100%
Kozubek A.
Acta Biochimica Polonica
|
1987
|
tom 34
|
nr 4
357-367
2
Content available remote The effect of 5-(n-alk(en)yl)resorcinols on membranes. II. Dependence on the aliphatic chain length and unsaturation
84%
Kozubek A.
Acta Biochimica Polonica
|
1987
|
tom 34
|
nr 4
387-394
3
Content available remote Determination of octanol/water partition coefficients for long-chain homologs of orcinol from cereal grains
84%
Kozubek A.
Acta Biochimica Polonica
|
1995
|
tom 42
|
nr 2
247-251
4
Content available remote Liposomal drug delivery, a novel approach: PLARosomes.
67%
Kozubek A. , Gubernator J. , Przeworska E. , Stasiuk M.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 3
639-649
EN
Almost from the time of their rediscovery in the 60's and the demonstration of their entrapment potential, liposomal vesicles have drawn attention of researchers as potential carriers of various bioactive molecules that could be used for therapeutic applications in humans and animals. Several commercial liposome-based drugs have already been discovered, registered and introduced with great success on the pharmaceutical market. However, further studies, focusing on the elaboration of more efficient and stable amphiphile-based vesicular (or non-viral) drug carriers are still under investigation. In this review we present the achievements of our group in this field. We have discovered that natural amphiphilic dihydroxyphenols and their semisynthetic derivatives are promising additives to liposomal lipid compositions. The presence of these compounds in lipid composition enhances liposomal drug encapsulation, reduces the amount of the lipid carrier necessary for efficient entrapment of anthracycline drugs by a factor of two, stabilizes liposomal formulation of the drug (both in suspension and in a lyophilized powder), does not influence liposomal fate in the blood circulation system and benefits from other biological activities of their resorcinolic lipid modifiers.
5
Content available remote Proteolysis of spectrin by trypsin and pronase in the presence of phospholipid suspensions
67%
Sikorski A. F. , Kozubek A. , Szopa J.
Acta Biochimica Polonica
|
1988
|
tom 35
|
nr 2
71-81
6
Content available remote Cereal grain resorcinolic lipids inhibit H_20_2-induced peroxidation of biological membranes
67%
Kozubek A. , Nienartowicz B.
Acta Biochimica Polonica
|
1995
|
tom 42
|
nr 3
309-315
7
Content available remote Modulation of some nuclear matrix enzymatic activities by free fatty acids
51%
Łubocka J. , Szopa J. , Kozubek A.
Acta Biochimica Polonica
|
1995
|
tom 42
|
nr 2
217-220
8
Content available remote Modification of the lipid component modulates nuclear matrix nucleolytic activity
51%
Łubocka J. , Szopa J. , Kozubek A.
Acta Biochimica Polonica
|
1995
|
tom 42
|
nr 2
211-215
9
Content available remote Interaction of alkylresorcinols with proteins
42%
Kozubek A.
Acta Biochimica Polonica
|
1995
|
tom 42
|
nr 2
241-246
first rewind previous Strona / 1 next fast forward last
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.