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Acute tubular necrosis (ATN) was described in canine babesiosis. Hypotension is considered as one of the factors which influence the development of hypoxic renal damage. In this study hypotension defined as mean arterial pressure (MAP) < 80 mmHg was detected in 7 out of 48 dogs (14.6%) infected with Babesia canis. Lower systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and MAP were detected in azotaemic dogs infected with B. canis. Statistically significant negative correlations between blood pressures (SAP, DAP and MAP) and serum creatinine and urea concentrations showed the influence of decreased blood pressure on the development of azotaemia and is probably also associated with ATN in canine babesiosis.
EN
The increase of the serum urea to creatinine ratio (UCR) was observed in dogs infected with Babesia canis. Previous studies have suggested that decrease of blood pressure can be one of the reasons for this phenomenon. In this work statistically significant increase of the UCR was observed in dogs with babesiosis. Comparison of the UCR between 23 azotaemic dogs and 25 non-azotaemic dogs infected with Babesia canis showed statistically significantly higher mean of the UCR in azotaemic dogs. Correlations between UCR and systolic, diastolic and mean arterial pressure (SAP, DAP and MAP) in 48 dogs infected with B. canis were negative (UCR and SAP: r = −0.3909; UCR and DAP: r = −0.3182; UCR and MAP: r = −0.3682) and statistically significant (p < 0.05). This result may indicate contribution of hypotension in the increase of the UCR in canine babesiosis. However, the correlations were not high, and there was no statistically significant correlation between UCR and arterial pressures in azotaemic dogs. Thus, it seems that decrease of blood pressure in dogs with babesiosis explains only partially the cause of increased UCR in infected dogs. The other authors suggested hyperureagenesis and myocardial injury as a potential reason for the increased UCR in canine babesiosis. Thus, further studies are needed to determine causes of increased UCR in dogs with babesiosis, especially on the connection between UCR changes and the concentrations of plasma cardiac troponins and ammonia, and the occurrence of occult blood on fecal examination.
EN
The influence of anaemia on alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) activities in dogs infected with B. canis was investigated. Samples of blood and serum from 230 infected dogs were divided into two groups: A (with anaemia) and B (without anaemia). The differences in the activities of the enzymes between both groups were not statistically significant. These results suggest that mild anaemia, as the only factor, has no influence on ALT, AST, or ALP activity in canine babesiosis. However, this study certainly cannot exclude the possibility that a more severe anaemia can have a major effect on the liver.
EN
Hydrocephalus is an anomaly caused by an excessive accumulation of cerebrospinal fluid in the ventricular system of the brain and/or subarachnoid space. It leads to neurological disorders in humans and animals. Prenatal injuries, such as viral infections or drug intoxications, may cause congenital hydrocephalus in cats. Moreover, a dry form of feline infectious peritonitis (FIP), toxoplasmosis or some brain neoplasms (e.g. ependymoma) may lead to the development of acquired hydrocephalus in cats. In this report the authors describe a case of a 5-month-old Burmese cat with incontinence and a plantigrade posture as leading symptoms of acquired hydrocephalus. Hydrocephalus was diagnosed using the magnetic resonance imaging (MRI) technique. Moreover, inflammatory foci were detected in the medulla oblongata, whereas a cerebrospinal fluid analysis revealed lymphocytic pleocytosis and an increased protein concentration. These clinicopathological findings are typical of the neurological form of the dry FIP. The cat was euthanized because the hydrocephalus was inflammatory and its cause was most probably infectious. This case report shows the practical use of MRI in veterinary practice.
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