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1 Acta Neurobiologiae Experimentalis

1 2009

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The phenotype of newly generated cells in the adults' brain of some species of rhinolophidae

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Ghazaryan A. , Djavadian R. , Yavrouyan E. , Turlejski K.

Acta Neurobiologiae Experimentalis

2009

tom 69

nr 3

In the brain of adult mammals neurogenesis continues in two regions: the dentate gyrus (DG) and subventricular zone of the lateral ventricles (SVZ). Here we present data concerning neurogenesis in brains of Rhinolophus (Rh) ferrumequinum, Rh euryale, Rh mehely and Rh hipposideros. These bats were captured on permission of the Ministry of Environment of Armenia. After capture all bats were injected with bromodeoxyuridine (BrdU, 300 mg/kg). Seven to nine days later animals were perfused transcardially with 4% paraformaldehyde in narcosis. We used immunohistochemical double-labeling to characterize the phenotype of newly generated cells. Colocalization of BrdU with NeuN (marker of mature neurons), glial fi brillary acidic protein (GFAP, astrocytic marker) and 2`,3`cyclic nucleotide phosphatase (CNP, oligodendrocytic marker) was examined using confocal microscope. We found that in both neurogenic regions the rate of neurogenesis was highest in Rhinolophus ferrumequinum and lowest in Rh mehely. Double-immunolabeling showed that in all neurogenic regions of the bats’ brain the neuronal phenotype dominated among newly generated cells, while proportion of astrocytes was low. BrdU colocalized with CNP in only a few cells in the SVZ of Rh ferrumequinum. We suggest that the rate of neurogenesis in different species may depend on the bats’ ecology.