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Novel electron mobility model for n-HgCdTe

100%

Yoo S. D. , Ko B. G. , Lee G. S. , Park J. G. , Kwack K. D.

Opto-Electronics Review

1999

tom Vol. 7, No. 4

339-345

In the conventional simulations for HgCdTe device, the empirical mobility model is used which lacks in generality. Especially, the field dependent mobility is found to be wrong by comparing Monte Carlo results. The semi - empirical electron mobility model for the simulator is proposed in this paper. Low field mobility consists of two terms related to ionised impurity and phonon scattering. It is calculated by using the relaxation time approximation, which gives the information on the dominant factors affecting the mobility. The ionised impurity mobility model is modified based on Brooks - Herring model to include the degeneracy effect and overlap integral. For field dependent mobility, a new formula is proposed to take into account features of the dominant scattering mechanism such as nonparabolic relation between energy and wave function at high field. Final formula is accomplished by introducting fitting parameters extracted from Monte Carlo simulation results. This new model retains more physical meaning than conventional model.

Numerical simulations for HgCdTe related detectors

86%

Yoo S. D. , Jo N. H. , Ko B. G. , Chang J. , Park J. G. , Kwack K. D.

Opto-Electronics Review

1999

tom Vol. 7, No. 4

347-356

In this paper we introduce a new HgCdTe 2-dimensional numerical simulator, HanYang University Semiconductor Device Simulator (HYSEDES). HYSEDES adopts the modifield transport models to describe the inherent natures of HgCdTe such as the degeneracy, the nonparabolic conduction band, and the band offset at heterointerface. It also takes into account various generation - recombination mechanisms regarding tunnelling phenomena and optical generation. For the advanced devices employing multiple junctions, all the material parameters are described as a function of the position. The simulation results are reported for photovoltaic devices and focal plane array. We also proposed a structure to improve the characteristics in focal plane array, i. e., to reduce crosstalk with slight degrading quantum efficiency.

Micro-sample analysis of capsaicin by liquid chromatography-tandem mass spectrometry assay and application to oral absorption study

72%

Choi Y. , Shin B. S. , Kim M. G. , Shin S. W. , Choo H. W. , Kim T. H. , Jang H. C. , Yoo S. D.

2013

tom Vol. 25, no. 2

363--376

Capsaicin has been reported to exhibit an inhibitory effect on the P-glycoprotein (P-gp) function in vitro. To investigate its concentration-dependent effect in vivo, a sensitive assay that can characterize the absorption and disposition of capsaicin needs to be developed. This study reports the development of a sensitive LC-MS/MS assay for the determination of capsaicin in mouse plasma. The sample pretreatment involved a one-step extraction of 20 μL plasma with t-butyl methyl ether. Separations were achieved on a C18 column and the detection was performed on an LC-ESI-MS/MS by multiple reaction monitoring. The assay was linear over a wide concentration range from 0.325 to 650 ng mL-1 (r > 0.999), with a LLOQ of 0.325 ng mL-1. The developed method was applied to i.v. (dose 0.325 and 0.65 mg kg) and oral absorption (dose 40 mg kg) studies in mice. After i.v. injection, the t1/2,λz, Vz and CLs ranged from 0.13–0.16 h, 127.6–141.8 mL, and 547.3–775.4 mL/h, respectively. After oral administration, a secondary peak was observed and the terminal half-life was prolonged (1.51 h). Capsaicin was poorly absorbed, with the absolute oral bioavailability (F) ranging from 1.02% to 1.56%. The developed assay may be useful in studies where sample volumes are limited.