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Sudden onset blindness treated with pulse steroid therapy in a patient with microscopic polyangiitis

100%

Horai Y. , Miyamura T. , Shimada K. , Takahama S. , Minami R. , Yamamoto M. , Suematsu E.

Open Medicine

2011

tom 6

nr 5

631-633

We report a 71-year-old male with microscopic polyangiitis (MPA) who developed sudden-onset, progressive, bilateral visual loss associated with a relapse of MPA symptoms. The patient was referred to our hospital, and treated with intravenous pulse steroid therapy and high-dose oral prednisolone. Although the right eye remained vision deficient, visual acuity in the left eye recovered. Ocular manifestations of MPA are quite uncommon. This case emphasizes the necessity of early detection and initiation of prompt therapy where ocular manifestations of MPA occur.

Severe aplastic anemia in a patient with rheumatoid arthritis after introduction of etanercept

84%

Horai Y. , Miyamura T. , Shimada K. , Ishida M. , Takahama S. , Minami R. , Yamamoto M. , Suematsu E.

Open Medicine

2012

tom 7

nr 5

650-654

A 73-year-old female, diagnosed with rheumatoid arthritis (RA), complicated with severe levels of joint destruction, started etanercept (ETN) because of high persistent RA disease activity. Although her articular symptoms dramatically improved, she developed marked pancytopenia after the introduction of ETN. Bone marrow aspirate specimen revealed hypocellular marrow in three hematopoietic series without atypical findings, which was compatible with aplastic anemia (AA). This is a rare case of severe pancytopenia due to AA presumably induced by ETN.