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Mimicking the morphology of long bone

100%

Ficai A. , Andronescu E. , Ficai D. , Sonmez M. , Albu M. , Voicu G.

Open Chemistry

2012

tom 10

nr 6

1949-1953

The aim of this work was to mimic the stratified structure of the median region of long bones. Starting from this desideratum, more COLL/HA composite materials with different morphology were synthesized and characterized, each of these materials mimicking one layer of long bone (endo- and periosteum, compact and cancellous bony tissue). Stratified bone grafts were obtained by assembling these layers; the obtained grafts were similar to the median region of long bones. Even though, natural bones have a more complex microstructure, this is a pioneering work since for the first time a stratified COLL/HA composite material similar to bone was produced. [...]

New approaches in layer by layer synthesis of collagen/hydroxyapatite composite materials

100%

Ilie A. , Andronescu E. , Ficai D. , Voicu G. , Ficai M. , Maganu M. , Ficai A.

Open Chemistry

2011

tom 9

nr 2

283-289

The aim of this work was to increase our understanding of collagen (COLL)/ hydroxyapatite (HA) composite materials; more specifically, we focused on the study of the influence of the precursorconcentrations over the final content of deposited HA. We found that the increase of the precursor concentrations led to better mineralization (on the basis of the content of deposited mineral phase). Regardless of the precursor concentrations, the content of the deposited amount was found to increase with the increase of the number of deposited layers. Quantification of the mineral phase amount was achieved by gravimetric determination. Based on the determined deposition equation the number of layers can be easily determined in order to obtain composite materials with desired content of mineral phase.