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Crosstalk between adiponectin and cytokines (IL-6 and IL-8) during transportation stress in horses

100%

Wessely-Szponder J. , Belkot Z. , Bobowiec R. , Wojcik M. , Kosior-Korzycka U.

tom 70

nr 09

According to recent research, during transportation stress, many organs, including skeletal muscles, undergo rapid and extensive adaptive changes, resulting among others in the expression of myokines. This response may evoke systemic inflammation reflected by changes in the cytokine profile. The aim of our study was to assess changes in plasma concentrations of IL-6, IL-8 and adiponectin in response to long- and short-distance transportation of young and middle-aged horses. The study was conducted on 24 cold-blooded female horses divided into four groups. Six fillies aged 6-18 months and six mares aged 10-12 years were transported over a distance of about 550 km, whereas six fillies aged 6-18 months and six mares aged 10-12 years were transported over a distance of about 50 km. Plasma was obtained from blood samples taken before transportation (T0), immediately after transportation (T1) and at an abattoir during slaughter (T2). Plasma concentrations of IL-6, IL-8 and adiponectin were measured with ELISA kits. The highest concentration of IL-6 was found in fillies after long-distance transportation during slaughter: it amounted to 978 ± 98 pg/ml, compared with 400 ± 90.60 pg/ml before transportation. The IL-8 level was maximal during slaughter (T2) in all groups, and was higher in older horses and after long-distance transportation than in fillies and after short-distance transportation. A significant change in adiponectin level was found only in the group of fillies after long-distance transportation. We demonstrated that during transportation stress, the concentrations of IL-6 and IL-8 increased in the blood of horses examined, and this response was more pronounced during slaughter. The concentration of adiponectin, on the other hand, increased significantly in fillies after long-distance transportation.