Wyniki wyszukiwania - Biblioteka Nauki

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Immunofenotyp nietypowy w ostrej białaczce szpikowej dorosłych chorych - jako korzystny czynnik prognostyczny

100%

Balana-Nowak A. , Bulinska K. , Piatkowska-Jakubas B. , Skotnicki A.

Diagnostyka Laboratoryjna

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2004

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tom 40

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nr 3

2

Multiplex real-time PCR to identify a possible reinfection with different strains of human cytomegalovirus in allogeneic hematopoietic stem cell transplant recipients

88%

Zawilinska B. , Szostek S. , Kopec J. , Piatkowska-Jakubas B. , Kosz-Vnenchak M.

Acta Biochimica Polonica

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2016

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tom 63

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nr 1

3

Detection of specific lytic and latent transcripts can help to predict the status of Epstein-Barr virus infection in transplant recipients with high virus load

75%

Zawilinska B. , Kosinska A. , Lenart M. , Kopec J. , Piatkowska-Jakubas B. , Skotnicki A. , Kosz-Vnenchak M.

Acta Biochimica Polonica

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2008

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tom 55

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nr 4

693-699

EN

Epstein–Barr virus (EBV), a member of the family Herpesviridae, is widely spread in the human population and has the ability to establish lifelong latent infection. In immunocompetent individuals the virus reactivation is usually harmless and unnoticeable. In immunocompromised patients productive infection or type III latency may lead to EBV-associated post-transplant lymphoproliferative disorder (PTLD). The aim of our research was to investigate the utility of PCR-based methods in the diagnosis and monitoring of EBV infections in bone marrow transplant recipients. Thirty-eight peripheral blood leukocyte samples obtained from 16 patients were analysed, in which EBV DNA was confirmed by PCR. We used semi-quantitative PCR to estimate the viral load and reverse-transcription PCR (RT-PCR) to differentiate between latent and productive EBV infection. In 14 patients we confirmed productive viral infection. We observed a correlation between higher number of EBV genome copies and the presence of transcripts specific for type III latency as well as clinical symptoms.

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Co-infections with herpesviruses after allogeneic hematopoietic stem cell transplantation (allo-HSCT)

75%

Zawilinska B. , Piatkowska-Jakubas B. , Szostek S. , Kopec J. , Malska-Wozniak A. , Kosz-Vnenchak M.

Postępy Mikrobiologii. Suplement

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2017

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tom 56

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nr 3

5

Clinical presentation of extraintestinal infections caused by non-typhoid Salmonella serotypes among patients at the University Hospital in Cracow during an 7-year period

63%

Kedzierska J. , Piatkowska-Jakubas B. , Kedzierska A. , Biesiada G. , Brzychczy A. , Parnicka A. , Miekinia B. , Kubisz A. , Sulowicz W.

Polish Journal of Microbiology

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2008

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tom 57

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nr 1

EN

The most characteristic finding in non-typhoid salmonella (NTS) infection is acute food related outbreaks of gastroenteritis, which is usually benign and self-limiting. However, more serious extraintestinal findings, such as bacteraemia and focal infections localized to any organ may appear. The objective of this paper is to describe the most important characteristic of the extraintestinal infections due to NTS serotypes observed in University Hospital, in Cracow between January 2000 and December 2006. To do so, we reviewed the clinical presentations, risk groups, complications and outcomes of in-patients, in which extraintestinal non-typhoid Salmonella serotypes were isolated, applying a clinomicrobiological protocol. Out of 30 patients with either bacteraemias (n = 22) or focal salmonella infections (n = 8), 12 had malignancies, 17 had immune dysfunction state, 9 had gastrointestinal disorders and 8 had chronic heart, pulmonary or kidney disease. Four of these patients (13%) who had hematological malignancies (2), renal transplantation (1) and pulmonary disease (1) died. Regarding the clinical picture, primary bacteraemia and focal infections occurred with similar frequency (33.3% and 26.7%, respectively); the remaining were bacteraemias secondary to gastroenteritis. The incidence rate (mean 0.30/1000 hospital admission/year) increased steadily from 0.19/1000 to 0.32/1000 hospital admission during the study period. From 30 Salmonella isolates from extraintestinal samples collected, only four isolates were resistant to ampicillin, ciprofloxacin or trimethoprim-sulfamethoxazole. This finding indicate that multidrug resistance does not represent a serious problem among NTS serotypes collected from the our medical center as monitored over a period of 7 years. Given this presentation, clinicians need to have a high index of suspicion and to consider preemptive therapy, especially in elderly patients who are likely to develop severe immunosuppression following interventions.