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Badanie dzialania drazniacego i uczulajacego katalizatora radowego

100%

Steplewski Z. , Jaskolecki H. , Malecka H. , Tyrpien M. , Stehlik E.

nr 4

271-273

Określono działanie drażniące i uczulające acetoacetonianodikarbonylorodu i trifenylofosfiny - składników katalizatora rodowego.

Experiments were conducted on rabbits and guinea-pigs to investigate the irritating and sensitizing action of acetylacetone-dicarbonyl-rhodium (AACRh) and triphenylphoshine being components of rhodium catalyst. AACRh was found to exert a slight irritating action on the rabbits' skin and eye's conjuctiva, being also a medium-strong sensitizer. Triphenylphosphine had no irritative action but caused strong sensitization. Basing upon the findings of this investigation, the authors suggest a complete air-tight sealing of manufacturing processes when rhodium catalyst is used, and the in- admissibility of subjects with allergic predispositions to the work at these processes.

Dynamics of changes in vascular endothelial growth factor (VEGF) expression and angiogenesis in stress-induced gastric ulceration in rats

100%

Malara B. , Josko J. , Tyrpien M. , Malara P. , Steplewska K.

nr 2

Angiogenesis and VEGF play a major role in many repair processes such as healing of gastric ulceration.The present study was undertaken to assess the dynamics of changes in VEGF expression and angiogenesis in stress-induced gastric ulcers in rats. Acute gastric ulceration was induced using a water-immersion and restraint stress method. The VEGF expression, angiogenesis, size of area and depth of ulcers in gastric speciments were evaluated. The study shows that as early as one day after the development of ulcers there is a significant increase in both the expression of the VEGF protein and the number of newly formed microvessels, while an abrupt decrease in VEGF expression, observed on the fifth day, results in a decreased intensity of angiogenesis. Moreover, it has been demonstrated that the increase in VEGF expression and angiogenesis is accompanied by a reduction in the size of area and depth of stress-induced ulcers in rats. Six days after ulcer development both VEGF expression and angiogenesis return to normal levels.

Badanie toksyczności alfa-sulfonowanych estrów metylowych kwasów tłuszczowych (alfa-SEMKT)

86%

Steplewski Z. , Jaskolecki H. , Malecka H. , Konecki J. , Steplewska-Mazur K. , Tyrpien M. , Stehlik E.

tom 26

nr 3