Wyniki wyszukiwania - Biblioteka Nauki

1

The effects of prenatal exposure to methylxanthines

100%

Skopinski P. , Woronkowicz M. , Skopinska-Rozewska E. , Siwicki A. K.

Polish Journal of Veterinary Sciences

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2011

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tom 14

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nr 4

EN

This review discusses epidemiology and laboratory studies on the effects of prenatal methylxanthine administration on some systems developing organisms. They are mainly absorbed from coffee, tea and cocoa products such as cola beverages and chocolate bars. Prenatal methylxanthine exposure can induce several unfavourables changes in the developing organism, which are persistent even in later phases of life. Based on results obtained from animal studies, the effect on embryogenesis is not only poorly understood but also controversial. It is therefore important to study interspecies differences as results may differ depending on animals used and administration methods.

2

Teophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition

100%

Chorostowska-Wynimko J. , Kus J. , Skopinska-Rozewska E.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

3

Rhodiola rosea in vitro culture - phytochemical analysis and antioxidant action

100%

Furmanowa M. , Skopinska-Rozewska E. , Rogala E. , Hartwich M.

Acta Societatis Botanicorum Poloniae

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1998

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tom 67

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nr 1

4

The effect of herbal remedy on the development of Trichinella spiralis infection in mice

100%

Bany J. , Zdanowska D. , Zdanowski R. , Skopinska-Rozewska E.

Polish Journal of Veterinary Sciences

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2003

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tom 06

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nr 3 Suppl.

5

Certain characteristics of human lymphocyte migration inhibitory of ampicillin on their apperance in unstimulated and PHA-stimulated cultures

100%

Skopinska-Rozewska E. , Madalinski W. , Lukasik R.

Acta Physiologica Polonica

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1983

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tom 34

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nr 3

6

Biological effects of conjugated linoleic acids supplementation

100%

Oleszczuk J. , Oleszczuk L. , Siwicki A. K. , Skopinska-Rozewska E.

Polish Journal of Veterinary Sciences

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2012

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tom 15

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nr 2

EN

Conjugated linoleic acids (CLA) are a group of polyunsaturated fatty acids (PUFA) with a single pair of conjugated double bonds. The major natural CLA isomer is 18:2 cis-9, trans-11 (c9, t11) linoleic acid, or rumenic acid (RA). Chemically synthesized CLA is also available, mostly as a mixture of RA and 18:2 trans-10, cis-12 (t10, c12) isomers in equal amounts (50:50). Consumption of ruminant meat (beef and lamb) and dairy products (milk and cheese) is the main source of dietary exposure to CLA. Despite numerous studies on animal and human models (tumorigenesis, obesity, immune response) it has not been established whether additional supplementation of CLA is of benefit. Moreover, some studies, conducted both in animals and in humans, reveal that CLA isomers may induce insulin resistance. Presently, balanced diet rich in CLA from natural sources is recommended. The purpose of this review was to sum up the results available in the literature.

7

The natural killer cells (NK) of human neonatal lymphocytes

88%

Gawrychowski K. , Majewski S. , Skopinska-Rozewska E. , Kaminski P. , Marianowski L.

Archivum Immunologiae et Therapiae Experimentalis

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1990

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tom 38

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nr 1-2

8

Ampicillin effect on lymphatic tissue of mice and its reaction to sheep erythrocytes

88%

Moscicka-Wesolowska M. , Skopinska-Rozewska E. , Morzycka-Michalik M. , Mioduszewska O. , Nowicka E.

Acta Physiologica Polonica

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1983

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tom 34

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nr 3

9

Feeding pregnant and lactating mice Rhodiola kirilowii extracts helps to preserve thymus function of their adult progeny

88%

Bien K. , Lewicki S. , Zdanowski R. , Skopinska-Rozewska E. , Krzyzowska M.

Polish Journal of Veterinary Sciences

|

2016

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tom 19

|

nr 3

EN

Plants belonging to Rhodiola kirilowii species, members of Rhodiola genus and Crassulaceae family, grow wildly in Tibet, Mongolia and China mountains and are traditionally used as adaptogens, antidepressants and anti-inflammatory remedies. Nowadays, R. kirilowii is cultivated in some countries, also in Poland. In our previous papers we reported immuno- and angio-modulatory effects of aqueous and hydro-alcoholic extracts of radix and rhizome of this plant in non-pregnant and pregnant mice. The aim of the present study was to evaluate the effect of feeding pregnant and further lactating mice these extracts on selected thymus function parameters in adult progeny. The counts of M-30+ apoptotic cells, in the thymuses obtained from progeny of mice fed during pregnancy and lactation water or 50% water-alcoholic extract of Rhodiola kirilowii, were significantly lower (p<0.05) than apoptotic cells counts observed in the control mice. No significant differences in the counts of IL-7-positive cells in the thymuses obtained from progeny of the control mice and mothers treated with water or hydro-alcohol extracts of Rhodiola kirilowii were observed.

10

Lymphocyte mitogen-induced proliferation in patients with allergic rhinitis

88%

Chorostowska-Wynimko J. , Kleniewska D. , Sokolnicka I. , Rogala E. , Skopinska-Rozewska E.

Archivum Immunologiae et Therapiae Experimentalis

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1995

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tom 43

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nr 3-4

11

In vivo inhibitory effect of Aloe vera gel on the ability of mouse parental splenic lymphocytes to induce cutaneous angiogenesis in recipient F1 mice

76%

Skopinski P. , Lewicki S. , Balan B. J. , Kocik J. , Zdanowski R. , Skopinska-Rozewska E. , Siwicki A. K.

Polish Journal of Veterinary Sciences

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2014

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tom 17

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nr 1

EN

Lymphocyte-induced angiogenesis test (LIA) is a model of local graft-versus-host (GVH) reaction, marker of the earliest events resulting from activation of donor lymphocytes after contact with host semi-allogeneic histocompatibility antigens. The effect of in vivo oral administration of Aloe vera gel for 21 days to maternal strain (Balb/c) donor mice on the ability of their splenic lymphocytes to induce cutaneous angiogenesis (LIA test) in F1 Balb/c x C3H recipients, was studied. Results: Neovascular reaction evaluated 72 hours after cells grafting was significantly lower in F1 mice grafted with lymphocytes collected from Aloe- fed donors, than in recipients of lymphocytes collected from respective controls. Conclusions: This observation opens the promise of safe and ethically acceptable possibility of use of Aloe vera gel in human donors in prevention of GVHD in recipients of bone marrow grafts.

12

The influence of different Rhodiola extracts on murine tumor cells angiogenic activity

76%

Skopinska-Rozewska E. , Mscisz A. , Sommer E. , Skopinski P. , Furmanowa M. , Mrozikiewicz P. M.

Herba Polonica. Suplement

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2005

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tom 51

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nr 1

13

Influence of Echinacea purpurea intake during pregnancy on fetal growth and tissue angiogenic activity

76%

Barcz E. , Sommer E. , Nartowska J. , Balan B. J. , Chorostowska-Wynimko J. , Skopinska-Rozewska E.

Folia Histochemica et Cytobiologica. Supplement

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2007

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tom 45

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nr 1

35-39

14

The influence of Eleuterococcus senticosus on cellular and humoral immunological response of mice

76%

Rogala E. , Skopinska-Rozewska E. , Sawicka T. , Sommer E. , Prosinska J. , Drozd J.

Polish Journal of Veterinary Sciences

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2003

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tom 06

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nr 3 Suppl.

15

Effects of homogenization of induced sputum by dithiothreitol on polymorphonuclear cells

76%

Van Overveld F. J. , Demkow U. , Gorecka D. , Skopinska-Rozewska E. , De Backer W. A. , Zielinski J.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 4

143-154

EN

Induced sputum represents a useful and non-invasive tool to isolate different cells from the airways. Complete homogenization of sputum is important for dispersion of cells and is usually achieved by use of dithiothreitol (DTT). However, it is not known if DTT will influence the viability and functionality of cells obtained by induced sputum. In the present study, induced sputum was processed by DTT or by PBS treatment. The obtained neutrophils were compared with neutrophils obtained from peripheral blood and from bronchoalveolar lavage fluid (BAL). These isolated neutrophils were treated in a similar way as the sputum neutrophils with DTT or PBS. All isolated cells were used for chemiluminescence tests and for the measurement of elastase and myeloperoxidase release after stimulation with fMLP. The results showed that the maximum chemiluminescence response was always significantly lower after DTT treatment: blood, 16.68 ±1.89 vs. 2.62 ±0.43 mV, P<0.0001; sputum, 2.96 ±0.30 vs. 1.09 ±0.01 mV, P<0.01; BAL, 25.47 ±0.88 vs. 8.22±0.20 mV, P<0.0001. Both spontaneous and fMLP-induced release of elastase and myeloperoxidase (MPO) was in most cases enhanced after DTT-treatment (P-values range from 0.24 to <0.01). We conclude that the use of DTT to homogenize sputum for dispersion of cells is harmful to cell functions and these cells are hampered for the evaluation of their normal functional characteristics.

16

Aktywnosc immunotropowa wyciagow roslinnych. II. Wplyw wyciagow wodnych z lisci i paczkow topoli na migracje leukocytow in vitro

76%

Malkowska-Zwierz W. , Glinkowska G. , Rogala E. , Strzelecka H. , Sikorska E. , Skopinska-Rozewska E.

Herba Polonica

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1995

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tom 41

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nr 2

80-83

EN

The effect of water extracts from folium and bud poplar on migration of peripheral blood granulocytes and lymphocytes from healthy donors were examined. We observed strong suppresive effect of folium extract and no influence of bud extract on lymphocytes migration. We suppose that this difference depends on presence of gentisic acid in bud extract. Although we observed suppressive effect of both extracts (stronger for bud) on human granulocytes migration. This effect appeared only in highest concentrations.

PL

W wyciągach z pączków i liści topoli poszukiwano czynników mogących wpływać na migrację granulocytów i limfocytów krwi obwodowej zdrowych osób. Przypuszcza się, że w przypadku limfocytów hamowanie migracji w obecności wyciągu z liści topoli i brak wpływu wyciągu z pączków był spowodowany stymulującym wpływem kwasu gentyzynowego, który prawdopodobnie znosi hamujący efekt innych, obecnych w obu wyciągach czynników. Wpływ obu wyciągów na granulocyty był hamujący, w większym stopniu w przypadku wyciągu z pączków niż liści i tylko w najwyższym stężeniu.

17

Disturbed angiogenic activity in sera from obstructive sleep apnea patients

76%

Chorostowska-Wynimko J. , Radomska D. , Plywaczewski R. , Jonczak L. , Stepniewska A. , Gorecka D. , Skopinska-Rozewska E.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 4

71-77

EN

It is increasingly recognized that obstructive sleep apnea (OSA) syndrome is a systematic rather than local disorder. There is also growing evidence that apart from the syndrome's major features: intermittent hypoxia and sleep fragmentation, functional activity of the immune system is altered in OSA patients, with several cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) taking active part in sleep regulation. Little is known about the effects exerted by chronic intermittent hypoxia combined with persistent pro-inflammatory activity of the immune system on the vascular micro milieu in OSA. In this study we attempted to confirm the hypothesized imbalance between pro- and anti-angiogenic factors by evaluating direct and indirect angiogenic activity of OSA patients' sera in the in vivo serum-induced angiogenesis (SIA) and leukocyte-induced (LIA) assays, respectively, in mice. Both tests revealed significantly inhibited angiogenic activity of OSA patients' sera compared with healthy controls (P<0.001). Moreover, differences related to the subject’s weight regarding in the mean number of newly-formed vessels were observed with a significantly greater inhibition in the normal-weighing apneic subjects than in the overweight or obese ones (P<0.01). The angiogenesis inhibition index was positively related to the serum IL-6 level (r=0.35; P<0.05) in the OSA group, but not to TNF-alpha, fasting serum leptin, or OSA syndrome severity as assessed by the AHI index. Our results demonstrate that OSA is accompanied by disturbed serum angiogenic activity, apparently resulting from an imbalance between pro- and anti-angiogenic factors, some of them being produced by the adipose tissue. The disordered angiogenic activity might be related to the pathophysiology of OSA and should be considered an important causative factor for the increased prevalence of cardiovascular diseases in OSA patients.

18

Inhibitory effect of Greenland shark liver oil combined with squalen and Arctic birch ashes on angiogenesis and L-1 sarcoma growth in Balb/c mice

76%

Skopinska-Rozewska E. , Chorostowska-Wynimko J. , Krotkiewski M. , Rogala E. , Sommer E. , Demkow U. , Skurzak H.

Polish Journal of Veterinary Sciences

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2003

|

tom 06

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nr 3 Suppl.

19

In vitro angiomodulatory activity of sera from type 2 diabetic patients with background retinopathy

76%

Chorostowska-Wynimko J. , Skopinski P. , Szaflik J. , Partyka I. , Duda-Krol B. , Anuszewska E. , Skopinska-Rozewska E.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

|

nr 4

65-70

EN

Diabetic retinopathy is the leading cause of adult vision loss and blindness. The most important contributors to the development of diabetic retinopathy are hyperglycemia and hypoxemia that lead to increased vasopermeability, endothelial cell proliferation, and pathological neovascularization. In our previous studies, close relationship between proangiogenic activity of sera from type 2 diabetes mellitus patients (DM2) with background retinopathy, assessed in the in vivo serum-induced mouse cutaneous test (SIA), and VEGF and IL-18 serum concentration were observed. Moreover, it was clearly shown that IGF-1 might play an important role in the negative regulation of neoangiogenesis induced by DM2 patients' sera by diminishing the VEGF stimulatory effect. To confirm the observed phenomenon we evaluated the effect of DM2 patients' sera on the in vitro proliferative activity of human endothelial cells, which is critical for the sprouting and generation of new blood capillaries. Endothelial proliferative activity was significantly higher in the presence of sera from DM2 patients than from healthy controls (P<0.001), as estimated by the MTT test. Moreover, the examined sera from DM2 patients were characterized by increased IL-18 (P<0.05), diminished IGF-1 (P<0.02), and unchanged VEGF levels compared with those in controls. In conclusion, the present study showed a strong stimulatory effect of DM2 patients' sera on the proliferation of endothelial cells, which, along with the findings of our previous studies, proves that the described phenomenon is universal and valid for both animal and human endothelium.

20

The influence of Rhodiola quadrifida 50 per cent hydro-alcoholic extract and salidroside on tumor-induced angiogenesis in mice

76%

Skopinska-Rozewska E. , Malinowski M. , Wasiutynski A. , Sommer E. , Furmanowa M. , Mazurkiewicz M. , Siwicki A. K.

Polish Journal of Veterinary Sciences

|

2008

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tom 11

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nr 2

97-104

EN

The genus Rhodiola (Crassulaceae) consists of more than 100 species. They grow mainly in Tibet, China and Mongolia and are traditionally used as tonic, adaptogen , antidepressant and anti-inflammatory drugs. The best known is Rhodiola rosea (R. rosea) now cultivated also in Europe and North America, and present on the market as dietary supplement. Some authors reported anti-tumor activity of R. rosea extracts. Recently, we have published some data on immunomodulatory and antiangiogenic properties of R. rosea. Rhodiola quadrifida (R. quadrifida) belongs to the same family, but is almost not known in Europe, and there is no information about its possible anti-tumor as well as immunotropic and angiotropic activity. The aim of this study was to determine the influence of 50% hydro-alcoholic extract from rhizomes of R. quadrifida (Mongolian origin) and its main biologically active compound salidroside on tumor-induced angiogenesis. Angiogenesis was induced in the skin of Balb/c mice by grafting of syngeneic L-l sarcoma cells. Mice were fed R. quadrifida extract or salidroside in daily doses 40, 200 and 400 μg, or 0.5, 1, 2, and 4 μg, respectively. After 72 hours, mice were sacrificed with lethal dose of Morbital. All newly formed blood vessels were identified and counted in dissection microscope. Results: It was found that R. quadrifida extract and salidroside highly significantly decreased neovas- cular reaction in all doses applied.