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1 Archivum Immunologiae et Therapiae Experimentalis

1 2000

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Role of immune-derived diffusible mediators in AIDS-associated neurological disorders

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Ensoli F. , Fiorelli V. , De- C. M. , Santini M. D. , Novi A. , Isgro A. , Aiuti F.

Archivum Immunologiae et Therapiae Experimentalis

2000

tom 48

nr 4

259-266

Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.