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Exploring the effect of xenon on biomembranes

100%

Stimson L. M. , Vattulainen I. , Rog T. , Karttunen M.

nr 4

Modelling the Solubility of Gases in Saturated and Substituted Perfluoroalkanes

86%

Dias A. , Pamies J. , Vega L. , Coutinho J. , Marrucho I.

2006

tom Vol. 80, nr 1

143-152

The importance of the study of fluorinated molecules is justified by the innumerous applications that these compounds are founding in many diverse and interesting areas as a consequence of their unusual properties. They are being used as substitutes for chlorinated solvents, surfactants in supercritical solvents, environmental probes, and in numerous biomedical applications. The choice of the best fluoroalkane to be used for a given application depends on its properties and in some cases, such as in biomedical applications, that choice has to be precise. Thus, the knowledge of the thermodynamic properties of these compounds is of extreme importance as well as the ability to describe and predict them at different conditions using thermodynamic models. In this work, the soft-SAFT EoS is used to describe the solubility of gases as oxygen, xenon and radon in saturated and substituted perfluoroalkanes. The conclusions reached in this work corroborate the experimental evidences reported in the literature indicating that the interaction between the oxygen and the CF3 terminal group is stronger than the interaction between the oxygen and other fluorinated groups in the molecule.

In vitro-evaluation of lipid emulsions as vehicles for the administration of xenon: Interaction with NMDA receptors

72%

Weigt H. U. , Georgieff M. , Fohr K. J. , Adolph O.

tom 69

nr 2

207-216

The noble gas xenon is an antagonist of the NMDA (N-methyl-D-aspartate)-type glutamate receptor which may account for the ideal anesthetic profile and potent neuroprotective properties demonstrated even at subanesthetic concentrations. Because lipid emulsions also promote NMDA antagonistic effects they may serve as ideal carriers for xenon. In this in vitro study, we investigated the efficacy of xenon dissolved in various lipid emulsions (Intralipid®, Lipofundin®, ClinOleic® and Abbolipid®) on NMDA-evoked currents in cultured cortical neurons. The NMDA receptor blocking property at a clinically relevant concentration seen in the lipid emulsions tested may contribute to the anesthetic, analgetic and neuroprotective effects of xenon administered by way of these lipid carriers. Abbolipid® may serve as the most acceptable carrier since the NMDA antagonistic effect of xenon was enhanced in combination with this emulsion.