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1 Journal of Physiology and Pharmacology

1 2002

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The role of GABAA receptors in the neural systems of the ventromedial-infundibular region of the hypothalamus in the control of gonadotropin release during the luteal phase in ewes

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Tomaszewska-Zaremba D. , Mateusiak K. , Przekop F.

Journal of Physiology and Pharmacology

2002

tom 53

nr 4,2

To examine the role of GABAA receptor mediating systems in the control of gonadotropin-releasing hormone (GnRH) release from the ventromedial- infundibular region (VEN/NI) in ewes during luteal phase, the extracellular concentrations of GnRH, ß-endorphin, noradrenaline (NE), dopamine (DA), and their metabolites: MHPG and DOPAC were quantified by local stimulation or blockade of GABAA receptors with muscimol or bicuculline, respectively. Stimulation of GABAA receptors in the VEN/NI did not affect GnRH, ß-endorphin release or catecholaminergic system activity. Blockade of GABAA receptors decreased ß-endorphinergic and dopaminergic activity, and lowered the extracellular concentration of MHPG. It did not affect GnRH release or luteinizing hormone (LH) secretion. It is suggested that progesterone-induced GABAergic activity during the luteal phase may desensitize GABAA receptors to muscimol. Lack of changes in GnRH/LH secretion with concomitant depressed ß-endorphinergic activity corroborated the conclusion that ß-endorphin does not inhibit GnRH release from the VEN/NI during the luteal phase. The physiological significance of changes in the catecholaminergic system activity under GABAA receptor blockade in the control of GnRH secretion awaits to be established.