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Adeno-associated virus vector-mediated gene delivery to the vasculature and kidney.

100%

Kapturczak M. H. , Chen S. , Agarwal A.

2005

tom 52

nr 2

293-299

Relatively successful elsewhere, gene delivery aimed at the vasculature and kidney has made very little progress. In the kidney, the hurdles are related to the unique structure–function relationships of this organ and in the blood vessels to a variety of, mostly endothelial, factors making the delivery of transgenes very difficult. Among gene-therapeutic approaches, most viral gene delivery systems utilized to date have shown significant practical and safety-related limitations due to the level and duration of recombinant transgene expression as well as their induction of a significant host immune response to vector proteins. Recombinant adeno-associated virus (rAAV) vectors appear to offer a vehicle for safe, long-term transgene expression. rAAV-based vectors are characterized by a relative non-immunogenicity and the absence of viral coding sequences. Furthermore, they allow for establishment of long-term latency without deleterious effects on the host cell. This brief review addresses problems related to transgene-delivery to kidney and vasculature with particular attention given to rAAV vectors. The potential for gene therapy as a strategy for selected renal and vascular diseases is also discussed.

Counter current transfer of oxytocin in vasculature of cows broad ligament

100%

Koziorowski M. , Stefanczyk-Krzymowska S. , Czarnocki J. , Krzymowski T.

tom 37

nr 4-6

The morphological analysis of vasculature in thyroid tumours: immunoexpression of CD34 antigen

84%

Rzeszutko M. , Rzeszutko W. , Dziegiel P.

nr 4

Two types of vascularisation of intramural uterine leiomyomata revealed by corrosion casting and immunohistochemical study

84%

Walocha J. A. , Miodonski A. J. , Szczepanski W. , Skrzat J. , Stachura J.

nr 1

The blood supply of myomatous uteri collected upon autopsy was examined. The uterine vascular beds were perfused via afferent vessels with fixative followed by Mercox resin and corroded after polymerisation of the resin. The vascular casts thus obtained were examined using scanning electron microscopy. The vascular system of the uterine fibroids was also examined using immunohistochemical analysis (FVIII, factor VIII-related antigen).

Occurrence and coexistence of some neuropeptides in nerve fibres supplying the bovine ovary and its extrinsic blood vessels

84%

Kaleczyc J. , Majewski M. , Lakomy M. , Sienkiewicz W.

nr 3

Microvasculature of the human fetal laryngeal anterior commissure

84%

Strek P. , Nowogrodzka-Zagorska M. , Miodonski A. J. , Olszewski E.

nr 4