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Arterial structure and function and its short- and long-term changes after bariatric surgery

100%

Gluszewska A. , Gryglewska B. , Rewiuk K. , Zarzycki B. , Dzieza-Grudnik A. , Kwater A. , Major P. , Budzynski A. , Gasowski J. , Grodzicki T.

tom 70

nr 6

Proliferative processes within the equine corpus luteum may depend on paracrine progesterone actions

80%

Ferreira-Dias G. , Costa A. S. , Mateus L. , Korzekwa A. , Redmer D. A. , Skarzynski D. J.

nr 8

139-151

Soon after ovulation, the corpus luteum (CL) starts secreting progesterone (P4), a hormone necessary for implantation. The aim of the study was to evaluate whether P4 exerts an autocrine/paracrine action on luteal angiogenic activity and P4, prostaglandin E2 (PGE2) and NO production in the mare. Corpora hemorrhagica (CH) and mid-luteal phase CL (MCL) were cultured with (i) no hormone (Control); (ii) P4; (iii) a P4 precursor - pregnenolone; or (iv) a P4 antagonist - onapristone [10-4M;10-5M; all steroids]. NO production decreased in MCL, with respect to CH, when treated with P4 [10-4M] and pregnenolone [10-5M]. PGE2 increased from CH to MCL, and showed a tendency to rise in pregnenolone treated luteal tissues (10-4M; p=0.06). In the CH, P4 decreased with pregnenolone [10-4M] compared to control, P4 [10-5M], onapristone [10-4M;10-5M] and pregnenolone [10-5M](p<0.05). In the MCL, pregnenolone [10-5M] decreased (p<0.05) and P4 tended to decrease (p=0.06) bovine aortic endothelial cell (BAEC) mitogenesis. Onapristone [10-4M] increased BAEC proliferation with respect to P4 (p=0.01). Since there was no direct effect of treatments on BAEC, these data suggest that long-lasting effects of P4 and its precursor may inhibit angiogenic factor(s) production by equine MCL, preparing for CL functional and structural regression.