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EN
Allergic reactions to COVID-19 vaccine ranging from mild to severe have been reported in patients with a history of anaphylaxis. Currently, no guidelines are available regarding prevention of allergic reactions in patients with high-risk of anaphylaxis who plan on receiving the SARS-CoV-2 vaccine. In this case-series study, two patients with a history of anaphylaxis had taken antihistaminic drugs prior to their BNT162b2 vaccinations and experienced no major allergic reactions afterwards. The use of antihistamines prior to COVID-19 vaccination may have affected the outcome of the two subjects with history of anaphylaxis history. However, further studies are needed to evaluate efficacy, generalizability and safety of the approach presented in this case-series.
EN
Introduction. Clear understanding of duration of antibody based protective immunity following natural infection with SARSCoV-2 will give idea about the efficacy of proposed prophylactic vaccines against SARS-CoV-2, establishment of herd immunity and use of convalescent plasma. Aim. This study clarified the kinetics and magnitude of the initial antibody response against SARS-CoV-2 in a cohort of symptomatic COVID-19 patients from Ibadan, Nigeria. Material and methods. This study quantified immunoglobulin M (IgM) and G (IgG) antibodies recognizing the SARS-CoV-2 Spike (S) protein in 35 symptomatic COVID-19 patients at admission and at discharge using ELISA. Results. CovIgG was positive in none (0)% and 20% of COVID-19 patients at admission and at discharge respectively while CovIgM was positive in 54% and 69% of COVID-19 patients at admission and at discharged respectively. The level of CovIgG was significantly higher in COVID-19 patients at discharge compared with the level at admission while the level of CovIgM was insignificantly reduced in COVID-19 patients at discharge compared with the level at admission. Conclusion. The data indicates increased anti-SARS-COV-2 IgG Spike antibody in symptomatic COVID-19 at discharge, thus providing basis for antibody-based therapies to treat COVID-19 patients
EN
The pandemic of the new coronavirus and the introduction of coronavirus vaccines prompted the production of vaccines and vaccine discourses around the world. The same situation has been observable in Japan. The purpose of this study is to discuss what I call “the social phenomenon of vaccines” in Japan. The present article will describe the characteristics of the vaccine discourse and consider the relationship between the vaccine discourse and vaccine-induced sufferings, which refer to the experience of social damages and difficulties caused by vaccines. Firstly, I will review the research method of the previous studies of vaccination. It has been shown that both pro-vaccine and anti-vaccine existed from the beginning of the history of vaccination, and in that sense, the existence of both pro-vaccine and anti-vaccine can be considered as a part of “the social phenomenon of vaccines” from the beginning. Inspired by the Strong Program, I will explain a method which would enable me to describe both pro and anti-vaccine without a priori assumptions. One such method can be found in the repertoire analysis by Gilbert and Mulkey (1984), who analyzed controversies in scientific research. Following their method, I will explore how the vaccine discourse was developed in Japan. The vaccine discourse in Japan is found in three different types of literature, which discuss vaccine promotion, vaccine harms, and vaccine safety. Secondly, I will identify three kinds of repertoires: “componentist repertoire”, “manipulationist repertoire” and “psychologism repertoire”. I will then discuss the features of “the social phenomenon of vaccines” by examining the relationship among these repertoires and how these repertoires work. Finally, I will discuss how vaccine discourse is related to the discourse of vaccine-induced sufferings. In conclusion, vaccination, by its very nature, cannot be separated from the impossibility of direct experience of vaccination. Therefore, the more vaccine develops, the more vaccine discourse flourishes.
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The aim of article is representation of the silhouette professors Koprowski, his scientific achievements. Hilary Koprowski was co-founder vaccine against poliomyelitis. I described childhood and youth professors, his scientific achievements, publications and related exam by him positions. I discussed controversies about vaccine against disease Heinego-Medina. Writing about achievements mentioned awards and decorations for scientific activity. I presented autobiographical books and biographical sacred profeesor Koprowski. At the end found themselves curiosities and another information from life professor.
EN
The goal of the studies was to evaluate the protective value of vaccines against pasteurellosis in rabbits. The vaccines comprised antigens to serotypes 3 and 12 of Pasteurella multocida with two different adjuvants: emulsigen and aluminium hydroxide gel. The two vaccines given subcutaneusly either once or twice at a dose of 1 ml protected rabbits markedly against intranasal infection with the virulent strains of examined serotypes. A substantial efficacy of these vaccines was supported by the occurrence of specific precipitins against somatic antigens of serotypes 3 and 12 present in the sera of immunised rabbits even 5 weeks after vaccination
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