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Uveal melanoma - a review of treatment methods

100%

Domańska A. , Piekarz D. , Pieniążek B. , Pijas N. , Piecewicz-Szczęsna H.

OphthaTherapy

2023

tom 10

nr 4

245-252

Uveal melanoma is the most common primary intraocular malignancy. In Europe, the incidence of uveal melanoma is approximately 8 cases per million people per year. In about 50% of cases, uveal melanoma metastasizes. Scientific papers on uveal melanoma published between 1 January 2018 and 1 March 2023, available in the PubMed database were analyzed. Currently, methods such as enucleation, transpupillary thermotherapy, photodynamic therapy, eye plaque brachytherapy, proton beam therapy and stereotactic surgery are used to treat this cancer. In this paper we summarize the current knowledge about the classic treatment methods and the promising novel ones.

Quantitative analysis of Gamma Knife stereotactic radiosurgery for uveal melanoma

88%

Bisht R. K. , Natanasabapathi G. , Kale S. S.

Polish Journal of Medical Physics and Engineering

2020

tom Vol. 26, Iss. 2

111--117

The purpose of the study was to analyze single fraction Gamma Knife stereotactic radiosurgery (SRS) for uveal melanoma (UM). In the treatment of UMs, the dose distribution exhibited by an irregular eye surface has more calculation uncertainty. A tissue-equivalent bolus was placed on the left eye surface of a human head-shaped phantom. It was assumed that the treated eye is fixed using retrobulbar anesthesia and suture on extraocular muscles for phantom study. Leksell stereotactic frame was fixed around phantom’s head and the stereotactic computed tomography (CT) was performed. Two sets of scans were acquired (a) without bolus and (b) with a bolus of 1.0 cm thickness. These scans were transferred into a treatment planning system (TPS). The skull contouring was performed using stereotactic CT images. The target, visual pathways, and eye lens were delineated in stereotactic CT space created on TPS. A clinical relevant plan was designed on the CT study set “a” to deliver a radiation dose of 30Gy at tumor margin. The plan superimposed over CT study set “b” and compiled for convincing treatment strategy. The tumor coverage was 95% at 50% prescription isodose line. The conformity index, selectivity and the gradient index were 1.27, 0.80 and 3.28 respectively. The left optic nerve and eye lens received a maximum dose of 11.1 Gy and 11.0 Gy respectively. The treatment plan overlay showed similar planning indices and critical organ doses. The plan comparison showed: an irradiated volume received the radiation dose > 15 Gy varies < 1.0% whereas the volume received < 15 Gy were larger (> 1.0%) in the study set “b”. The distant lateral points from the target volume which describe the phantom’s eyelid showed a radiation dose of 3.2 Gy - 2.5 Gy. The doses to these points were misled and ignored in the CT study set “a”. The eye bolus provides better dosimetric information in the estimation of low dose areas which is commonly misled on TPS in SRS planning for UMs.

Diverse expression of N-acetylglucosaminyltransferase V and complex-type β1,6-branched N-glycans in uveal and cutaneous melanoma cells

75%

Pocheć E. , Rydlewska M. , Przybyło M. , Lityńska A.

Acta Biochimica Polonica

2015

tom 62

nr 2

323-328

Although both uveal (UM) and cutaneous (CM) melanoma cells derive from the transformed melanocytes, their biology varies significantly in several aspects. Malignant transformation is frequently associated with alternations in cell glycosylation, in particular those concerning branched complex-type N-glycans. These changes occur principally in β1,4-N-acetylglucosaminyltransferase III (GnT-III) that catalyzes the synthesis of glycans with bisected N-acetylglucosamine (GlcNAc) and β1,6-N-acetylglucosaminyltransferase V (GnT-V) that is involved in forming β1,6-branched antenna in complex-type glycans. We searched for the reasons of a different behavior of CM and UM cells in the expression of GnT-III and GnT-V and their oligosaccharide products. Our study showed that UM cells have more β1,6-branched glycans than CM cells, what results from a higher expression of MGAT5 gene encoding GnT-V. The higher β1,6-branching of glycans in UM may contribute to their higher potential to migrate on fibronectin and weaker binding to main extracellular matrix proteins, observed in our previous studies.

Downregulation of polo-like kinase-1 (PLK-1) expression is associated with poor clinical outcome in uveal melanoma patients

63%

Berus T. , Markiewicz A. , Kobylinska K. , Biecek P. , Orlowska-Heitzman J. , Romanowska-Dixon B. , Donizy P.

Folia Histochemica et Cytobiologica

2020

tom 58

nr 2

Expression of P53 protein in primary uveal melanoma

63%

Sulkowski S. , Sulkowska M. , Famulski W. , Chyczewski L. , Bakunowicz-Lazarczyk A.

Folia Histochemica et Cytobiologica

2001

tom 39

nr 2

Expression of caveolin-1 in human cutaneous and uveal melanoma cells

51%

Belkot K. , Bubka M. , Litynska A.

Folia Biologica

2016

tom 64

nr 3