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Inhibitors of bacterial and plants urease. A review

100%

Macegoniuk K.

Acta Universitatis Lodziensis. Folia Biologica et Oecologica

2013

tom 9

9-16

Urease is an important virulence factor for Helicobacter pylori and Proteus mirabilis as well as in environmental transformations of certain nitrogenous compounds. Urea hydrolysis caused by these microorganisms leads to increased pH and ammonia toxicity and enables bacterial colonization of the human gastric mucosa and urinary tract formation of struvite and carbonate-apatite stones. Due to the possibility of medical applications the development of novel, selective and efficient classes of urease inhibitors which satisfy the low toxicity requirement for human health and have low environmental impact is necessary. In this article are described the various urease inhibitors used so far by researchers, especially in the last few years.

Impaired histamine binding by gastric juice of patients with duodenal ulcer

86%

Zak-Nejmark T. , Malolepszy J. , Liebhart J. , Kuczynska-Sekieta K. , Liebhart E. , Nadobna G.

Archivum Immunologiae et Therapiae Experimentalis

1989

tom 37

nr 1-2

The effects of environmental factors on the prevalence of Helicobacter pylori infection in inhabitants of Lublin Province

72%

Celinski K. , Kurzeja-Miroslaw A. , Slomka M. , Cichoz-Lach H. , Madro A. , Kasztelan-Szczerbinska B.

Annals of Agricultural and Environmental Medicine

2006

tom 13

nr 2

The aim of the study was to analyse the prevalence of H. pylori infection in adult inhabitants of Lublin Province. The effects of living conditions and lifestyle on the infection frequency were evaluated. The study included 585 adults randomly chosen for the epidemiological analysis of H. pylori infection in the Lublin region within the project commissioned by the Ministry of Health (PCZ 08-09) and State Committee for Scientific Research (C007/P05/2000). The study was based on a personal questionnaire and determinations of anti/Hp antibodies in IgG class using the ELISA method. High titres of anti/Hp antibodies (>24 IU/ml) were demonstrated in 78.5% of the subjects. In Lublin Province the infected individuals constitute 72% of inhabitants, in the big towns - 74% and in small towns - 95%. According to the place of birth: among those born in the country 87% are infected, compared to 78.4% in the small towns and 64% in the big towns, respectively. Positive test results were observed in 79% of farmers, 78% of manual workers and 75% of mental workers. The percentage of the affected neglecting basic hygienic rules exceeded 90%. With increased frequency of hygienic measures the number of the H. pylori infected individuals decreased to 65%. The prevalence of H. pylori infection among the inhabitants of the Lublin region is lower than that found in town inhabitants. Lublin Province shows the lowest level of H. pylori infection in Poland. The H. pylori infection is strongly affected by the lack of basic rules of personal hygiene and improper diet.

Prevalence of Helicobacter pylori in children dependently on age and living conditions

58%

Czkwianianc E. , Bak-Romaniszyn L. , Malecka-Panas E. , Suski S. , Woch G.

Journal of Physiology and Pharmacology

1996

tom 47

nr 1

The role of H. pylori infection in the pathophysiology of duodenal ulcer disease

51%

McColl K. E. L. , El-Omar E. M. , Gillen D.

Journal of Physiology and Pharmacology

1997

tom 48

nr 3

Helicobacter pylori from duodenal ulcer patients expresses inducible nitric oxide synthase immunoreactivity in vivo and in vitro

51%

Stachura J. , Konturek J. W. , Karczewska A. , Domschke W. , Popiela T. , Konturek S. J.

Journal of Physiology and Pharmacology

1996

tom 47

nr 1