This paper presents an analysis of the isotopic composition of spent nuclear fuel under different operating conditions. Calculations were made for fuel assemblies of a VVER-440 reactor with second-generation Gd-2 fuel with enrichment of 4.25% 235U. The isotopic concentration was analyzed as a function of burnup of nineteen isotopes, selected on the basis of environmental risk, such as main fuel isotopes 235U, 236U, 238U, 239Pu, 240Pu, 241Pu, as well as some actinides, and fission products, such as 237Np, 238Pu, 242Pu, 241Am, 242Am, 242Cm, 244Cm, 245Cm, 90S r, 93Zr, 99Tc, 129I, 137Cs. The SCALE 6 computer code was used for model design and computer analysis.
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