Wyniki wyszukiwania - Biblioteka Nauki

1

Immune response gene polymorphisms in tuberculosis

100%

Fol M. , Druszczynska M. , Wlodarczyk M. , Ograczyk E. , Rudnicka W.

Acta Biochimica Polonica

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2015

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tom 62

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nr 4

633-640

EN

Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (M.tb), remains a leading public health problem in most parts of the world. Despite the discovery of the bacilli over 100 years ago, there are still many unanswered questions about the host resistance to TB. Although one third of the world's population is infected with virulent M.tb, no more than 5-10% develop active disease within their lifetime. A lot of studies suggest that host genetic factors determine the outcome of M.tb-host interactions, however, specific genes and polymorphisms that govern the development of TB are not completely understood. Strong evidence exists for genes encoding pattern recognition receptors (TLR, CD14), C-type lectins, cytokines/chemokines and their receptors (IFN-γ, TNF-α, IL-12, IL-10, MCP-1, MMP-1), major histocompatibility complex (MHC) molecules, vitamin D receptor (VDR), and proton-coupled divalent metal ion transporters (SLC11A1). Polymorphisms in these genes have a diverse influence on the susceptibility to or protection against TB among particular families, ethnicities and races. In this paper, we review recent discoveries in genetic studies and correlate these findings with their influence on TB susceptibility.

2

Tuberculosis of gall-bladder mimicking malignancy – a case report

80%

Dahiya D. , Kaman L. , Rajendran J. , Garg M.

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tom 88(5)

504-509

EN

A correct preoperative diagnosis of gall-bladder tuberculosis is exceptionally unusual in the absence of pathognomic features both on clinical presentation and on imaging. Herein we present a case of 50 year female who was operated with a provisional diagnosis of gall-bladder malignancy and was found to have tuberculosis of gall-bladder on histopathology

3

Cervical lymphadenitis as a result of (Hijab) pin prick in north of Jordan

80%

Mahmoud M. Gharaibeh M. M. , Ahmed Al Wadiya A. A. , Ahmad Gharaibeh A.

European Journal of Clinical and Experimental Medicine

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2020

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nr 4

286-288

EN

Introduction. Cervical lymph nodes are lymph nodes found in the neck. Hijab is a head cover worn by some Muslim women in the presence of any adult male outside of their immediate family, which usually covers the head, neck and chest. It is strictly forbidden to Muslim woman to unveil any single hair of her head, so they use many pins around the head to fix their Hijab. Often, while using pins they are self-pricked. Aim. The main aim of our work is to reveal a new cause of lymphadenopathy, which is not known till now. Material and methods. Retrospective study during the past five years among seventy-five female outpatients, visited our Oral and Maxillofacial clinic in dental department. Our data was collected according to medical history of patients; all female patients with cervical lymphadenopathy were using (A hijab). Results. Data collected of 75 female patients. Lymphadenopathy causes were various. Most of these causes resulted from nonspecific lymphadenitis (67 patients), 4 tuberculosis, 2 lymphoma, 2 cat scratch disease. Aetiology of 67 nonspecific lymphadenitis was 40 patients of dental cause, 10 of sore throat, 7 of acne vulgaris, 3 of mild facial injuries, and 7 of (Hijab pin pricks). Conclusion. Hijab pin prick cervical lymphadenitis in Islamic communities is not uncommon and, unexplained cervical lymphadenitis should be considered as potential cause

4

A rare case of isolated pancreatic tuberculosis in a 70-year-old patient - a case report

80%

Słupski M. , Wiciński M. , Khuat D. , Pawlak-Osińska K.

Polish Journal of Surgery

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2019

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tom 91(2)

48-50

EN

We report a case of rare solitary pancreatic tuberculoma. 70 years old woman admitted to hospital in order to conduct diagnostics of a tumor located in the head of the pancreas. All symptoms pointed at pancreatic cancer, but histopathological examinations were inconclusive. Additionally, there were no clinical signs or symptoms of tuberculosis in the lungs. X-ray of the chest showed no abnormalities. The patient denied tuberculosis in the medical interview. There were no bacilli in the sputum. During exploratory laparotomy, the samples of tissue have been taken for pathomorphological examination. The microscopic image caused suspicion of Mycobacterium tuberculosis etiology, which was confirmed by Ziehl-Neelsen staining. In recent years, tuberculosis has become more and more common in Europe, which is why the described case can be a guide for doctors to help to avoid diagnostic errors and speed up the treatment process.

5

O życiu i działalności naukowej Eugenii Piaseckiej-Zeylandowej

80%

Siciński H.

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tom 8

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nr 1

67-71

PL

Artykuł przedstawia życie i działalność badawczą Eugenii Piaseckiej-Zeylandowej, wybitnej znawczyni problematyki prątka gruźlicy, docent Uniwersytetu Poznańskiego. Dla historii medycyny szczególną wartość mają informacje o jej ostatnich latach życia.

EN

The article describes Eugenia Piasecka-Zeylandowa, her life and research on the tubercle bacillus. Piasecka-Zeylandowa, reader of Poznan University, was an outstanding expert of issues of tuberculosis and BCG vaccination. This article provides information on her last years

6

Recenzja: Tuberculosis and War. Lessons Learned from World War II, eds. John F. Murray, Rober Loddenkemper, Progress in Respiratory Research Vol. 43, Series Editor Felix J. F. Herth. KARGER Basel 2018, ss. 232, il., ISSN 1422-2140, eISSN 1662-3932, ISBN 978-3-318-06094—2, e-ISSN 978-3-318-06095-9

80%

Magowska A.

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tom 8

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nr 1

99-100

PL

Recenzja

EN

Review

7

Multi Drug Resistant Tuberculosis

80%

Balaji Zacharia B. , Antony Roy A.

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nr 3

262-269

EN

Introduction. Tuberculosis is one of the oldest infections known to mankind. Of all infectious diseases, tuberculosis causes the most fatalities of any infection. The incidence of tuberculosis on the rise due to the increased prevalence of HIV infection. The incidence of drug resistance strains of mycobacterium is also on the rise. When the mycobacterium is resistant to both INH and rifampicin it is called multi drug resistant tuberculosis. There is a primary and an acquired type of drug resistance. Multidrug resistant tuberculosis is a not only a problem for the patient but also for society at large. The treatment of multidrug resistant tuberculosis requires an entirely different approach. Aim. In this review, we are going to describe the etiopathogenesis, diagnosis, investigations and treatment of multi drug resistant tuberculosis. Material and methods. Analysis of the current literature. Results. Genetic factors, previous treatment, and other factors predisposes the onset of drug resistance. By early detection and prevention of spread of drug resistant strains we can prevent the spread of resistant strains. Conclusion. Drug resistance in tuberculosis is a very complex and dangerous problem. We have to prevent the development and spread of MDRTB. Good quality drugs should be used and made available to all sections of the population. Enhancing the National tuberculosis programs is the best way to attain an effective way to control this menace.

8

Strengthening infrastructure in management of drug resistant tuberculosis in India

80%

Shrivastava S. , Shrivastava P. , Ramasamy J.

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tom 4

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nr 1

277-279

XX

The emergence of resistance to first-line drugs used to treat tuberculosis (TB) has become a significant public health concern and an obstacle in implementation of effective TB control activities globally. In India, Revised National TB Control Program (RNTCP) introduced the programmatic management of drug-resistant TB (PMDT) services to address the needs of MDR-TB patients. To execute the plan with perfection, RNTCP has devised MDR suspect criteria – A, B, and C so that gradually PMDT services can be extended to the whole country. These criteria were framed to run in tandem with the strengthening of the laboratory services so that the existing certified laboratories can carry out the culture and DST services without being overburdened. Altogether, RNTCP is committed for the strengthening and capacity building of its resources to offer culture and DST services right at the time of diagnosis.

9

Unfinished first-line tuberculosis treatment in primary care in Indonesia

70%

Asyary A. , Mahendradhata Y.

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nr 2

185-188

EN

Background. Unfinished tuberculosis (TB) treatment has slowly but surely become an unexpected event in the disease’s development into drug-resistant TB. Developing countries, mostly comprised of Asian and Eastern European countries, including Indonesia, have been overwhelmed in preventing drug-resistant TB outcomes and have also failed to avoid the development of this disease. Objectives. This review discusses the current issue of an unfinished first-line TB treatment strategy in primary care in Indonesia, presenting some relevant strategies in developing countries. Material and methods. A narrative review approach conducted on all existing evidence in selected scientific bibliographic sources. The researchers defined the keywords based on the research question as a search strategy. Results. Scarce resources and limited access, alongside national policy on TB control and management, contribute in different ways to impede first-line TB treatment in Indonesia. Empowerment of TB patients and their families are considered the best ways to increase awareness on TB medication in a low- to middle-income setting. The role of the hospital and private practitioner networks in the treatment and management of TB patients is essential for developing active-case-finding-approach programs for TB suspects in primary care in an Indonesian setting. Contrarily, the potential misunderstandings in TB treatment have led to peculiar events affected by poor surveillance systems for TB investigation contacts to prevent TB incidences in large populations. Conclusions. This study addressed the barrier of all stakeholders, particularly primary care, to achieve the Indonesian government’s goals of TB elimination by 2030 and zero TB findings by 2050

10

Can interferon-gamma release assays be useful for monitoring the response to anti-tuberculosis treatment?: a systematic review and meta-analysis

70%

Pourakbari B. , Mamishi S. , Benvari S. , Sauzullo I. , Bedini A. , Valentini P. , Keicho N. , Mahmoudi S.

Archivum Immunologiae et Therapiae Experimentalis

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2020

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tom 68

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nr 1

11

Haiguse kujutamine luuletaja Ilmi Kolla kirjades

70%

Annuk E.

Mäetagused

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2010

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tom 45

39-52

EN

Private letters are the least researched genre of autobiographical writings. Irrespective of this fact, letters can indeed offer abundant research material about the ailing person’s perceptions of the disease and how he/she depicts this in writing. The article dwells upon the depiction of disease, based on the letters by Ilmi Kolla (1933–1954), using the concept of (auto)pathography as an analytical means. The focus is on how the illness is being textualised in letters and how the epistolary genre affects such a depiction. Ilmi Kolla’s letters reflect the progress of her disease, presenting this from the author’s viewpoint, yet adapting it according the addressees – e.g., Ilmi Kolla’s letters to her mother are written in a more optimistic tone regarding her illness than the ones to poet Debora Vaarandi expressing greater concern. The letters reveal various facets of the disease and her state of mind with regard to the illness, presenting a picture of sanatorium and hospital treatment. In line with the growing severity of Ilmi Kolla’s disease, the illness becomes gradually more visible in her letters, encompassing increasing textual space. Thus, the ailment has become one of the main topics in I. Kolla’s letters sent from the hospital during the last six months of her life. The fact that letters tend to be fragmentary texts separated from each other by a temporal-spatial distance becomes evident in the narrative of disease constructed by the letters. Although such an illness narrative lacks coherence intrinsic of a traditional linear autobiographic text, such a life history or a diary, an epistolary story of an illness can be studied from the viewpoint of auto-pathography as the letters create an autobiographic description of the illness. As unpublished texts, letters can both reflect and oppose the discourses of the time. The depiction of the disease, and that of an ailing body, revealed in Ilmi Kolla’s letters, functions as a counter-discourse to the body image of the Stalinist era, which highlighted a healthy, strong and powerful female body. As such, the reflection of the disease in the letters actually brings out the cultural and gender-wise meanings related to the disease, highlighting the illness as a cultural construct.

12

A study on the mycobacterial burden and phenotypic drug resistance pattern with reference to the GeneXpert Cycle Threshold values in pulmonary tuberculosis

70%

Kashyap B. , Sarkar K. , Singh K. , Hyanki P.

European Journal of Clinical and Experimental Medicine

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2023

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nr 4

730-735

EN

Introduction and aim. Tuberculosis (TB) remains a significant global health challenge. Early and accurate diagnosis is crucial to prevent further transmission. The present study aimed to correlate cycle threshold values with smear microscopy and culture positivity, and determine cut-off cycle threshold values for levels of smear grade and culture positivity. Material and methods. Forty presumptive cases of pulmonary TB were included and subjected to Ziehl-Neelsen stain, culture on Lowenstein Jensen media, CBNAAT and drug susceptibility testing for first line anti-tubercular drugs. Results. Our study predicts 3+, 2+, and 1+ sputum smear grade at a cut-off of Ct value ≤ 16.74, ≤19.68, and ≤ 22.32 respectively. A strong positive correlation was found between time to culture positivity and Ct value. A cut-off of Ct value ≤22.32 predicts culture positivity with a sensitivity of 92%, and a specificity of 67%. None of the isolates showed rifampicin resistance by 1% proportion method. Conclusion. Understanding the appropriate utilization of CBNAAT Ct values and their correlation with smear microscopy grade, culture, and drug susceptibility testing can assist clinicians in early identification and prompt initiation of appropriate treatment. This knowledge can contribute to the prevention of drug resistance, reduced transmission, and a decreased disease burden associated with TB.

13

Living in the Corpse. Functions of Tuberculosis and Forms of Its Representation in Croatian Literature and Culture in the Late 19th and Early 20th Century

70%

Vuković T.

Poznańskie Studia Slawistyczne

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2017

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nr 13

PL

In the second half of the 19th century, social development based on science, technological innovation, rationalism and capitalist economy presents itself as full of promise insofar as it proclaims the upcoming progress of civilization. The downside of this process is the increase in crime, massive neurosis, various forms of moral disorder, and the epidemics of somatic diseases such as tuberculosis and syphilis. Consequently, the perception of the new generation as degenerate is actually the way to articulate anxiety in the culture of the time. Croatian literature at the end of the 19th and at the beginning of the 20th century frequently refers to illness, bodies burdened by drives, and to sick, tense or perverted minds. The paper, therefore, reads tuberculosis as a metaphor for the discontent and fear that permeate the contemporary Croatian society due to, for instance, the failure of the traditional concept of identity, changed gender roles, frequent sexual transgressions, increased mortality and generally due to the inefficiency of modernization processes in solving numerous social problems and crises.

14

Palaeopathology and its relevance to understanding health and disease today: the impact of the environment on health, past and present

60%

Roberts C. A.

Anthropological Review

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2016

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tom 79

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nr 1

1-16

EN

This paper considers the discipline of palaeopathology, how it has developed, how it is studied, and what limitations present challenges to analysis. The study of disease has a long history and has probably most rapidly developed over the last 40-50 years with the development of methods, and particularly ancient pathogen DNA analysis. While emphasizing that palaeopathology has close synergies to evolutionary medicine, it focuses then on three ‘case studies’ that illustrate the close interaction people have had with their environments and how that has impacted their health. Upper and lower respiratory tract disease has affected sinuses and ribs, particularly in urban contexts, and tuberculosis in particular has been an ever present disease throughout thousands of years of our existence. Ancient DNA methods are now allowing us to explore how strains of the bacteria causing TB have changed through time. Vitamin D deficiency and ‘phossy jaw’ are also described, both potentially related to polluted environments, and possibly to working conditions in the industrial period. Access to UV light is emphasized as a preventative factor for rickets and where a person lives is important (latitude). The painful stigmatizing ‘phossy jaw’ appears to be a condition related to the match making industries. Finally, thoughts for the future are outlined, and two key concerns: a close consideration of ethical issues and human remains, especially with destructive analyses, and thinking more about how palaeopathological research can impact people beyond academia.

15

Tuberkulostatyczne chemioterapeutyki

60%

Nowak K. , Suryło P. , Kowalski P.

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tom [Z] 57, 9-10

877--906

EN

At the present time tuberculosis is completely treatable. However, it[MS1] is still a major cause of morbidity and mortality among the poorest people. Tuberculosis is the main source of death from among infectious diseases worldwide. In turn, infectious diseases remain the leading cause of death in the world today, greater than cardiovascular disease or cancer. According to the data provided by World Health Organization (WHO), one-third of the world's population is infected with Mycobacterium tuberculosis. In contrary to general expectation, the incidence of mycobacterial disease has significantly increased since 1990 worldwide. This problem has been aggravated by the human immunodeficiency virus (HIV) pandemia and the recent increase in incidences of microbial resistance to antibiotics. Another problem is the lack of the viable research program to develop the new range of the antituberculosis drugs. Since the mid 90’s no new drugs have been introduced, with the exception of a few minor modifications of existing formulas. This review presents history and current summary of the developments in the application and synthesis of tuberculostatic chemotherapeutics. One of the first type of drugs used were salts of heavy metals, which were discontinued quickly due to the high degree of their toxicity. However pirazinamide(2), introduced in 1936 is still being used today. Modern antituberculosis therapies started in 1944 with the Waksman’s discovery of the streptomycin (12). From among modern drugs the most popular are: PAS (15), INH (18), and EMB (34). Schemes 7, 8 and 14, 15 show the methods of synthesis of these compounds. Similarly, schemes 9?11 show the same for the cycloserine (22) antibiotic, and figures 2, 3 and 4 present the structures of the kanamycin 33 cyclic polipeptide 38 and ansamycin 39 antibiotics. Furthermore, detailed description of the methods of synthesis of fluorochinolones 44, 45 and 46 (introduced in 80’s) can be found in schemes 19, 20 and 22. In this article there is also information about the direction of the new research trends taking place in the field of the new antituberculosis agents.

16

Prevalence of tuberculosis in cattle in Turkey

60%

Gumussoy K. S. , Atasever A. , Aydin F. , Ozcan M. , Beyaz L. , Hizlisoy H. , Abay S.

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tom 63

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nr 03

305-308

EN

The aim of the study was to determine the prevalence of bovine tuberculosis in the Kayseri province in Turkey and to compare histopathology and direct microscope examinations, culture and BACTEC radiometric methods. The lungs and bronchial and mediastinal lymph nodes, collected from 3216 cattle slaughtered at 5 slaughterhouses belonging to both the public and private sector, were examined from September 2003 to August 2004. In macroscopic examinations lesions were noted in 248 (7.7%) of the cattle. In histopathology examinations caseous tuberculosis was observed in 57% of the lungs, in 57% of the bronchial and in 53% of the mediastinal lymph nodes. In direct microscopy, acid-fast bacilli were seen in 33% of the lungs, in 33% of the bronchial and in 28% of the mediastinal lymph nodes. In culture, Mycobacterium bovis was isolated in 19% of the lungs, 19% of the bronchial and in 17% of the mediastinal lymph nodes. In the BACTEC method, Mycobacterium spp. was isolated in 21% of the lungs, in 21% of the bronchial and in 17% of the mediastinal lymph nodes. In conclusion, the prevalence of bovine tuberculosis in slaughtered cattle in Kayseri province is 1.49%, and the BACTEC radiometric method is a rapid and sensitive method for diagnosing M. bovis.

17

Powstanie i działalność łódzkiej sekcji Walki z Gruźlicą w latach 1918-1939

60%

Supady J.

Analecta. Studia i Materiały z Dziejów Nauki

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2013

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tom 22

|

nr 1-2

18

Szczepienia przeciw ospie prawdziwej oraz przeciw gruźlicy w opiniach lekarzy polskich w świetle wybranych tytułów polskiego czasopiśmiennictwa lekarskiego (1801–1900)

60%

Adamowicz A. , Płonka-Syroka B.

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2018

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tom 27

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nr 1(52)

157-204

EN

This article discusses the Polish doctors’ views on the issue of smallpox vaccine and tuberculosis vaccine. The cognitive aim of the study was to present the history of introducing both vaccines on the territory of Europe, show the Polish doctors’ opinions on this background and catch the similarities and differences in attitudes to both vaccines. Important factor is that smallpox vaccine was introduced before formulating the standard of microbiology, whereas tuberculosis vaccine was introduced after formulating this standard. Smallpox vaccine was introduced on the territory of Poland in 1801. Thanks to its effectiveness, the vaccine became a regular part of the prevention of infectious diseases. Polish doctors have frequently taken the subject of vaccination in periodicals, writing not only about its advantages and values, but also about many issues related to it. Tuberculin was accepted by the medical community as a revelation and miracle drug. However, after several months of trials, it exposed its imperfections, such as some complications (deterioration of the patient’s condition, death) and no cases of complete cure. For these reasons tuberculin was criticized by doctors and withdrawn from use.

19

The role of bronchoscopy in the diagnosis of lower respiratory tract infections

60%

Mierzejewski M. , Krenke R.

Polski Przegląd Otorynolaryngologiczny

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2016

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tom 5(3)

1-6

EN

Bronchoscopy was introduced into clinical practice over 100 years ago. Due to technological advances, diagnostic capabilities of current bronchoscopy are not limited to the trachea and proximal bronchi but also include the peripheral airways as well as various anatomical structures located outside the bronchi. A wide range of available techniques that include bronchoalveolar lavage, protected microbiological brush, transbronchial biopsy of the lungs and mediastinal lymph nodes makes bronchoscopy useful in diagnosing various lower respiratory tract infections. For example, the collection of high quality biological samples for microbiological examination plays a crucial role when treating patients with nosocomial pneumonia. Bronchoscopy may provide the samples directly from the site of infection. In immunocompromised hosts bronchoscopy is routinely used as the diagnostic tool in lower respiratory tract infections. Due to implementation of novel therapies, the number of immunocompromised patients is steadily increasing, hence there are growing needs for effective diagnosis of opportunistic pulmonary infections. In the specific group of lung transplant recipients, bronchoscopy play a crucial role in monitoring the rejection process and also in differentiating between the rejection and pulmonary infections. Bronchoscopy is also useful in diagnosing tuberculosis or nontuberculous pulmonary infections. This particularly refers to patients who are unable to produce sputum for microbiological examination.

20

Přátelství s Robertem Klopstockem. Poslední léta Franze Kafky

60%

Čermák J.

Historie – Otázky – Problémy (History, Issues, Problems)

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2013

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tom 5

|

nr 1

51-60

EN

On the basis of correspondence between Franz Kafka and Robert Klopstock, which was recently published by the author, this study presents the last years and days in the life of Franz Kafka, his connections with his family and friends and particularly with Klopstock, a medical student, who became acquainted with Kafka in 1921 at the Matliary sanatorium in the Tatras and with whom Kafka formed his last great friendship in life. Klopstock, who was himself literarily active, was very close to Kafka in the last years of his life; both were brought together by their intellectual interests. Kafka endeavoured to help Klopstock even materially, while Klopstock selflessly accompanied the writer in the last weeks of his life. This study also shows how classic medical ideas used in the treatment conflicted with Kafka’s own ideas and the efforts of his mistress Dora Diamantová, who advocated “natural cures”.