Wyniki wyszukiwania - Biblioteka Nauki

1

Effect of trimethoprim on trichloroethylene metabolism

100%

Zieba-Proc B. , Orlowski J.

Acta Poloniae Toxicologica

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1996

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tom 04

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nr 1

2

Antibacterial activity of ciprofloxacin and trimethoprim, alone and in combination, against Vibrio cholerae O1 biotype E1 Tor serotype Ogawa isolates

72%

Mandal S. , Pal N. K. , Chowdhury I. H. , Debmandal M.

Polish Journal of Microbiology

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2009

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tom 58

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nr 1

57-60

EN

In this communication, the ciprofloxacin-trimethoprim (Cp-Tm) combination showed synergistic (Fractional Inhibitory Concentration, FIC index 0.399) and additive (FIC index 0.665-0.83) effects against Vibrio cholerae O1 biotype El Tor serotype Ogawa isolates having Cp MICs 10 μg/ml and Cp 0.66 μg/ml, respectively, following agar dilution checkerboard method. The time-kill study results demonstrated synergy between Cp and Tm against both groups of isolates providing 2.04 log₁₀ (for strain with Cp MIC 0.66 μg/ml) and 3.12 log₁₀ (for strain with Cp MIC 10 μg/ml) decreases in CFU/ml between the combination and its most active compound. Thus, the findings of the present study suggest an introduction of Cp-Tm combination treatment regimen against drug resistant cholera and this in turn will help in combating the drug resistance of V. cholerae O1 biotype El Tor serotype Ogawa.

3

In situ methanolic solvent synthesis, spectroscopic and thermogravimetric characterizations of three new transition metal complexes of trimethoprim drug

72%

Refat M. S. , Al-Humaidi J. Y. , El-Sayed M. Y. , Hassan R. F.

Polish Journal of Chemical Technology

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2021

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tom Vol. 23, nr 1

60--67

EN

Trimethoprim drug (TMP) complexes of copper (II), cobalt (II), and nickel (II) were prepared and discussed by using elemental analysis (C, H, N analysis), magnetic, molar conductance, FTIR, Raman spectroscopy, electron spin resonance (ESR) and UV-vis spectroscopy analyses. TMP drug coordinated as a tridentate ligand towards the respected three metal ions through two nitrogen atoms of amino groups and nitrogen atom of pyrimidine ring which flanked between –NH2 groups, these assignments confirmed by spectroscopic, magnetic, ESR and thermogravimetric analyses with formulas [Cu(TMP)(H2O)3]Cl2, [Co(TMP)(H2O)3]Cl2 and [Ni(TMP) (H2O)]Cl2. Copper (II) and cobalt (II) complexes have an octahedral geometrical structure included one TMP molecule, three coordinated water molecules and two uncoordinated chlorine atoms while, nickel(II)–TMP complex has a tetrahedral geometric configuration that involved one TMP molecule, one coordinated water molecule and two uncoordinated chlorine atoms. The activation energies and other kinetic thermodynamic parameters were estimated based on the employed of the Coats-Redfern and Horowitz-Metzger equations. The nano–structured form of the synthesized TMP complexes was confirmed dependent on the transmission electron microscopy (TEM).

4

Adsorptive stripping voltammetry of trimethoprim at an in situ plated lead film electrode

72%

Korloczuk M. , Tyszczuk K.

Chemia Analityczna

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2007

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tom Vol. 52, No. 6

1015-1024

EN

An adsorptive stripping voltammetric procedure for the determination of trimethoprim at an in situ plated lead film electrode on glassy carbon substrate was described. The lead film plating process and accumulation of trimethoprim were performed simultaneously in an acetate buffer solution of pH = 5.8 and at potential -1.275 V. The measurements were carried out in undeaerated solutions. The calibration graph, for an accumulation time of 60 s, was linear in the range from 1 x 10-8 to 2x10-7 mol L-1. The detection limit was 3.5 x 10-9 mol L-1: the relative standard deviation for 1 x 10-7 mol L-1 trimethoprim was 4.2%. The proposed procedure was successfully applied to trimethoprim determination in pharmaceutical preparations and human urine samples.

PL

W pracy opisano procedurę oznaczania trimetoprimu na tworzonej in situ błonkowej elektrodzie ołowiowej na podłożu z węgla szklistego, metodą adsorpcyjnej woltamperometrii stripingowej. Tworzenie bionki ołowiu i zateżanie trimetoprimu przeprowadzano jednocześnie, z roztworu buforu octanowego o pH = 5,8, przy potencjale -1.275 V. Pomiary wykonywano z roztworów nieodtlenionych. Krzywa kalibracyjna przy czasie zatężania 60 s jest liniowawzakresieod l x 10-8 do 2x 10-7 mol L-1. Granica wykrywalności wynosi 3.5 x 10-9 mol L-1 a względne odchylenie standardowe, przy oznaczaniu trimetoprimu o stężeniu l x 10-7 mol L-1 wynosi 4,2%. Zaprezentowana procedura została wykorzystanado oznaczania trimetoprimu w preparatach farmaceutycznych i próbkach ludzkiego moczu.

5

Wplyw aniliny na wydalanie trimetoprimu z moczem u szczura

58%

Jodynis-Liebert J.

Bromatologia i Chemia Toksykologiczna

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1997

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tom 30

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nr 3

277-281

PL

W pracy podjęto próbę określenia wpływu aniliny w narażeniu wielokrotnym na przebieg wydalania trimetoprimu z moczem. Wykazano wzrost wydalania niezmienionego leku u szczurów eksponowanych na pary aniliny. Nie stwierdzono zasadniczych zmian w kinetyce wydalania trimetoprimu.

EN

Screening tests revealed that aniline increased urine trimethoprim (TMP) excretion in rat. The study attempted to investigate the effect of aniline under conditions of repeated exposure on the course of TMP excretion with urine. Two variants, A and B, of exposure were used. Aniline vapour concentration: 100 mg/m3. TMP p.o. dose: 16 mg/kg b.w. Three groups of rats (10 rats each) were exposed to aniline vapours 1, 4 and 10 times, 6 h a day. After the exposure series they were administered a single dose of TMP. Urine was collected at pre-determined intervals over 24-h period and TMP concentration was determined. An increase of urinary TMP concentration correlating with the number of inhalations was shown to occur. Kinetic parameters were calculated from the Bateman formula. No effect of aniline on the kinetics of TMP removal was observed. Three groups of rats (10 rats each) were used. Group I was exposed for 12 days (6 h a day) to aniline vapour. Group II received TMP only. Group III was exposed both to aniline and TMP. Concentrations of TMP and p-aminophenol (an aniline metabolite) were determined in the 24-h urine samples after 1, 6 and 12 days. The exposure to aniline vapours was found to cause almost 3-fold increase of TMP removal. No effect of TMP on p-aminiphenol excretion was observed.

6

Effects of trichloroethylene and trimethoprim on changes in the activity of enzymes involved in their metabolism

58%

Orlowski J. , Gnojkowski J. , Zieba B.

Acta Toxicologica

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2006

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tom 14

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nr 1-2