Wyniki wyszukiwania - Biblioteka Nauki

1

Body mass analysis in patients with Hashimoto thyroiditis

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Popławska-Kita A. , Siewko K. , Telejko B. , Kościuszko-Zdrodowska M. , Hryniewicka J. , Szelachowska M. , Milewski R. , Górska M.

Progress in Health Sciences

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2014

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tom 4

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nr 1

18-23

EN

Introduction: Hashimoto thyroiditis (HT) is one of the most common autoimmune thyroid disorders and o the most common cause of hypothyroidism, but the relation between TSH and body mass is still unclear. Material and methods: The group studied consisted of 53 patients with HT in euthyreosis and 28 healthy individuals. All the patients underwent thyroid ultrasonography and body mass analysis with the use of a medical analyzer INBODY 200. Blood samples were also analyzed for TSH and anti-thyroid antibodies. Results: The patients with HT had higher body mass (p=0.008), body mass index (BMI) (p=0.02), Waist-Hip Ratio (WHR) (0.01) and fat mass (p=0.02) than had the controls. In HT group increased body mass was observed in 72% of the patients (overweight in 38% and obesity in 35% of them), as compared with 38% of overweight/obesity in the control group. Thyroid volume was significantly lower (p=0.01) and anti-peroxidase antibodies level was two times higher in the group with the treatment period > 2 years, but the patients with relatively short treatment period were 7 kg heavier and their fat mass was 6 kg higher than in the subjects treated longer than 2 years. Conclusions: Our results suggest that the patients with HT, even in euthyreosis, have significantly higher body mass, BMI, WHR and fat mass than healthy individuals, which is probably associated with previous disturbances that led to the increase in fat mass at the stage of hypothyroidism. The observed changes tend to normalize during L-thyroxine replacement therapy.

2

Normal levels of TSH affect the metabolic profile differently in physically active males and females

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Malara M. , Keska A. , Tkaczyk J. , Lutoslawska G.

Central European Journal of Sport Sciences and Medicine

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2021

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tom 35

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nr 03

3

Dylematy diagnostyki czynności tarczycy

63%

Solnica B.

Laboratorium - Przegląd Ogólnopolski

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2008

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tom nr 10

56--59

PL

Schorzenia tarczycy wiodące do zaburzeń jej czynności endokrynnej występują często. Laboratoryjna ocena zaburzeń czynności tarczycy jest oparta na oznaczaniu stężenia we krwi hormonu tyreotropowego (TSH) oraz wolnej frakcji tyroksyny (FT4) i trijodotyrniny (FT3). Interpretacja wyników jest zgodna z zasadami regulacji wydzielania TSH, w tym ujemnego sprzężenia zwrotnego ze stężeniem FT3 i FT4. Ocena czynności tarczycy w oparciu o te badania może być utrudniona przy zaburzonej funkcji osi podwzgórze - przysadka - tarczyca. Wyniki powinny być ostrożnie interpretowane w ciężkich chorobach pozatarczycowych i w ciąży. Odmiennego podejścia wymaga monitorowanie leczenia substytucyjnego i tyreostatycznego. Wartości decyzyjne stężenia TSH powinny uwzględniać zmienność populacyjną i być dobierane empirycznie. Odrębny problem stanowi metodyka oznaczania wolnych hormonów tarczycy, która wymaga udoskonalenia.

EN

Diseases of the thyroid gland leading to its endocrine dysfunction are a very common ailment. Labaratory assessment of thyroid dysfunction is based on thyrotropin (TSH), free fractions of thyroxine (FT4) and triiodothyroine (FT3) blood concentration measurements. The interpretation of the results takes place in accordance with the rules of regulation of TSH secretion including negative feedback with FT3 and FT4 levels. However, the assessment of thyroid function based on these tests may be complicated in the case of the dysfunction of the hypothalamic- pituitary- thyroid axis. The results should be interpreted carefully in the case of severe nonthyroidal disorders, as well as during pregnancy. The monitoring of the replacement or thyrostatic treatment requires a different approach. The decision values of TSH concentration should comply population variability and be established empirically. Another issue makes the methodology of free thyroid hormones assays, which are in need of further improvement.

4

Thyroid hormone and thyreotropin (TSH) association with densitometric parameters in children

63%

Porwik E. , Matusik P. , Drzyzdzyk K.

Journal of Medical Informatics & Technologies

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2009

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tom Vol. 13

141--144

EN

The influence of TSH on bones is still vastly unknown and the information that is known is considered controversial. This important relationship has not been studied in detail. The aim of our research was to assess the correlation between TSH, thyroid hormone and bone mineral density in children measured by DXA scanning. Our study group included 36 children (16 girls and 20 boys) mean age 12.9 š 3.3 years. Basic anthropometrical measurements were performed (height, weight, body mass index-BMI), in all subjects. Blood was collected and measured for TSH and FT4. Bone mineral density of lumbar spine (L2-L4 BMD) and total body (Total Body BMD) were measured by DXA and expressed as bone mineral content (BMC [g]) and bone mineral density (BMD [g/cm2]). BMD Z-Score was also calculated. Correlation between the parameters obtained by DXA and anthropometrical data, TSH and thyroid hormone concentration were calculated. A statistically significant positive correlation was observed between height, weight and BMI and BMD which was calculated. Weight and BMI also had a statically significant correlation with Z-Score and total bone mineral content (BMC – expressed in grams). There was a statistically significant positive correlation between TSH level and Z-Score for both L2-L4 lumbar spine and for total body. TSH did not correlate significantly with BMD [g/cm2] and BMC [g]. FT4 was negatively and significantly correlated with Z-Score for both L2-L4 lumbar spine and for total body. There was also no significant correlation between FT4 and BMD [g/cm2] and BMC [g]. Conclusion: 1. Thyroid stimulating-hormone (TSH) appears to be associated with maintenance of bone mineral density in children. 2. BMD Z-Score especially from L2-L4 lumbar spine assessed by DXA scanning is correlated best with hormonal and biochemical factors potentially influencing bone mineralization in children.